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Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.

Publication ,  Journal Article
Fu, K; Weisenburger, DD; Greiner, TC; Dave, S; Wright, G; Rosenwald, A; Chiorazzi, M; Iqbal, J; Gesk, S; Siebert, R; De Jong, D; Jaffe, ES ...
Published in: Blood
December 15, 2005

Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial and difficult to substantiate. Our previous gene expression profiling study identified several cases that lacked cyclin D1 expression, but had a gene expression signature typical of MCL. Herein, we report the clinical, pathologic, and genetic features of 6 cases of cyclin D1-negative MCL. All 6 cases exhibited the characteristic morphologic features and the unique gene expression signature of MCL but lacked the t(11;14)(q13; q32) by fluorescence in situ hybridization (FISH) analysis. The tumor cells also failed to express cyclin D1 protein, but instead expressed either cyclin D2 (2 cases) or cyclin D3 (4 cases). There was good correlation between cyclin D protein expression and the corresponding mRNA expression levels by gene expression analysis. Using interphase FISH, we did not detect chromosomal translocations or amplifications involving CCND2 and CCND3 loci in these cases. Patients with cyclin D1-negative MCL were similar clinically to those with cyclin D1-positive MCL. In conclusion, cases of cyclin D1-negative MCL do exist and are part of the spectrum of MCL. Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 15, 2005

Volume

106

Issue

13

Start / End Page

4315 / 4321

Location

United States

Related Subject Headings

  • Lymphoma, Mantle-Cell
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Cyclin D1
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fu, K., Weisenburger, D. D., Greiner, T. C., Dave, S., Wright, G., Rosenwald, A., … Lymphoma/Leukemia Molecular Profiling Project, . (2005). Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood, 106(13), 4315–4321. https://doi.org/10.1182/blood-2005-04-1753
Fu, Kai, Dennis D. Weisenburger, Timothy C. Greiner, Sandeep Dave, George Wright, Andreas Rosenwald, Michael Chiorazzi, et al. “Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.Blood 106, no. 13 (December 15, 2005): 4315–21. https://doi.org/10.1182/blood-2005-04-1753.
Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005 Dec 15;106(13):4315–21.
Fu, Kai, et al. “Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.Blood, vol. 106, no. 13, Dec. 2005, pp. 4315–21. Pubmed, doi:10.1182/blood-2005-04-1753.
Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM, Müller-Hermelink HK, Campo E, Gascoyne RD, Staudt LM, Chan WC, Lymphoma/Leukemia Molecular Profiling Project. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood. 2005 Dec 15;106(13):4315–4321.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

December 15, 2005

Volume

106

Issue

13

Start / End Page

4315 / 4321

Location

United States

Related Subject Headings

  • Lymphoma, Mantle-Cell
  • Immunology
  • Humans
  • Gene Expression Profiling
  • Cyclin D1
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences