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Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.

Publication ,  Journal Article
Laskowitz, DT; Song, P; Wang, H; Mace, B; Sullivan, PM; Vitek, MP; Dawson, HN
Published in: J Neurotrauma
November 2010

Cognitive impairment is common following traumatic brain injury (TBI), and neuroinflammatory mechanisms may predispose to the development of neurodegenerative disease. Apolipoprotein E (apoE) polymorphisms modify neuroinflammatory responses, and influence both outcome from acute brain injury and the risk of developing neurodegenerative disease. We demonstrate that TBI accelerates neurodegenerative pathology in double-transgenic animals expressing the common human apoE alleles and mutated amyloid precursor protein, and that pathology is exacerbated in the presence of the apoE4 allele. The administration of an apoE-mimetic peptide markedly reduced the development of neurodegenerative pathology in mice homozygous for apoE3 as well as apoE3/E4 heterozygotes. These results demonstrate that TBI accelerates the cardinal neuropathological features of neurodegenerative disease, and establishes the potential for apoE mimetic therapies in reducing pathology associated with neurodegeneration.

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Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

November 2010

Volume

27

Issue

11

Start / End Page

1983 / 1995

Location

United States

Related Subject Headings

  • tau Proteins
  • Tumor Necrosis Factor-alpha
  • RNA, Messenger
  • Psychomotor Performance
  • Polymorphism, Genetic
  • Platelet-Derived Growth Factor
  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Motor Activity
  • Mice, Transgenic
 

Citation

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Laskowitz, D. T., Song, P., Wang, H., Mace, B., Sullivan, P. M., Vitek, M. P., & Dawson, H. N. (2010). Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma, 27(11), 1983–1995. https://doi.org/10.1089/neu.2010.1396
Laskowitz, Daniel T., Pingping Song, Haichen Wang, Brian Mace, Patrick M. Sullivan, Michael P. Vitek, and Hana N. Dawson. “Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.J Neurotrauma 27, no. 11 (November 2010): 1983–95. https://doi.org/10.1089/neu.2010.1396.
Laskowitz DT, Song P, Wang H, Mace B, Sullivan PM, Vitek MP, et al. Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma. 2010 Nov;27(11):1983–95.
Laskowitz, Daniel T., et al. “Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.J Neurotrauma, vol. 27, no. 11, Nov. 2010, pp. 1983–95. Pubmed, doi:10.1089/neu.2010.1396.
Laskowitz DT, Song P, Wang H, Mace B, Sullivan PM, Vitek MP, Dawson HN. Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma. 2010 Nov;27(11):1983–1995.
Journal cover image

Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

November 2010

Volume

27

Issue

11

Start / End Page

1983 / 1995

Location

United States

Related Subject Headings

  • tau Proteins
  • Tumor Necrosis Factor-alpha
  • RNA, Messenger
  • Psychomotor Performance
  • Polymorphism, Genetic
  • Platelet-Derived Growth Factor
  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Motor Activity
  • Mice, Transgenic