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Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.

Publication ,  Journal Article
Gómez de Barreda, E; Pérez, M; Gómez Ramos, P; de Cristobal, J; Martín-Maestro, P; Morán, A; Dawson, HN; Vitek, MP; Lucas, JJ; Hernández, F; Avila, J
Published in: Neurobiol Dis
March 2010

It has been proposed that deregulation of neuronal glycogen synthase kinase 3 (GSK3) activity may be a key feature in Alzheimer disease pathogenesis. We have previously generated transgenic mice that overexpress GSK3beta in forebrain regions including dentate gyrus (DG), a region involved in learning and memory acquisition. We have found that GSK3 overexpression results in DG degeneration. To test whether tau protein modified by GSK3 plays a role in that neurodegeneration, we have brought GSK3 overexpressing mice to a tau knockout background. Our results indicate that the toxic effect of GSK3 overexpression is milder and slower in the absence of tau. Thus, we suggest that the hyperphosphorylated tau mediates, at least in part, the pathology observed in the brain of GSK3 overexpressing mice.

Duke Scholars

Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

March 2010

Volume

37

Issue

3

Start / End Page

622 / 629

Location

United States

Related Subject Headings

  • tau Proteins
  • beta Catenin
  • Phosphorylation
  • Neurons
  • Neurology & Neurosurgery
  • Neurofibrillary Tangles
  • Nerve Degeneration
  • Mice, Transgenic
  • Mice, Knockout
  • Mice
 

Citation

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Gómez de Barreda, E., Pérez, M., Gómez Ramos, P., de Cristobal, J., Martín-Maestro, P., Morán, A., … Avila, J. (2010). Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis, 37(3), 622–629. https://doi.org/10.1016/j.nbd.2009.11.017
Gómez de Barreda, Elena, Mar Pérez, Pilar Gómez Ramos, Javier de Cristobal, Patricia Martín-Maestro, Asunción Morán, Hana N. Dawson, et al. “Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.Neurobiol Dis 37, no. 3 (March 2010): 622–29. https://doi.org/10.1016/j.nbd.2009.11.017.
Gómez de Barreda E, Pérez M, Gómez Ramos P, de Cristobal J, Martín-Maestro P, Morán A, et al. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis. 2010 Mar;37(3):622–9.
Gómez de Barreda, Elena, et al. “Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.Neurobiol Dis, vol. 37, no. 3, Mar. 2010, pp. 622–29. Pubmed, doi:10.1016/j.nbd.2009.11.017.
Gómez de Barreda E, Pérez M, Gómez Ramos P, de Cristobal J, Martín-Maestro P, Morán A, Dawson HN, Vitek MP, Lucas JJ, Hernández F, Avila J. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis. 2010 Mar;37(3):622–629.
Journal cover image

Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

March 2010

Volume

37

Issue

3

Start / End Page

622 / 629

Location

United States

Related Subject Headings

  • tau Proteins
  • beta Catenin
  • Phosphorylation
  • Neurons
  • Neurology & Neurosurgery
  • Neurofibrillary Tangles
  • Nerve Degeneration
  • Mice, Transgenic
  • Mice, Knockout
  • Mice