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Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder.

Publication ,  Journal Article
Tupler, LA; De Bellis, MD
Published in: Biol Psychiatry
March 15, 2006

BACKGROUND: Although many studies of adults with posttraumatic stress disorder (PTSD) have reported smaller hippocampal volume compared with control subjects, comparable studies of children and adolescents have failed to replicate these findings or have noted opposite trends suggesting a larger hippocampus. We therefore performed a secondary analysis combining data from prior studies to examine the hypothesis that hippocampus would be larger in pediatric subjects with PTSD compared with non-maltreated control subjects. We also hypothesized that differences in PTSD subjects would be observed between boys and girls. METHODS: Sixty-one subjects (31 boys, 30 girls) with maltreatment-related PTSD and 122 control subjects matched on age and gender underwent magnetic resonance imaging. RESULTS: As hypothesized, we observed a significantly larger hippocampus controlling for cerebral volume in PTSD subjects compared with control subjects. Segmented hippocampal white-matter volume was greater in PTSD subjects but not gray-matter volume. Hippocampal volume was positively related to age of trauma onset and level of psychopathology, particularly externalizing behavior. No interactions with group were observed for age or gender. CONCLUSIONS: Future longitudinal studies with trauma control subjects and neuropsychological measures are indicated to further elucidate the relationship between hippocampus and behavioral abnormalities in young PTSD subjects.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 15, 2006

Volume

59

Issue

6

Start / End Page

523 / 529

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Reference Values
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Internal-External Control
  • Image Processing, Computer-Assisted
  • Humans
  • Hippocampus
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tupler, L. A., & De Bellis, M. D. (2006). Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder. Biol Psychiatry, 59(6), 523–529. https://doi.org/10.1016/j.biopsych.2005.08.007
Tupler, Larry A., and Michael D. De Bellis. “Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder.Biol Psychiatry 59, no. 6 (March 15, 2006): 523–29. https://doi.org/10.1016/j.biopsych.2005.08.007.
Tupler LA, De Bellis MD. Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder. Biol Psychiatry. 2006 Mar 15;59(6):523–9.
Tupler, Larry A., and Michael D. De Bellis. “Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder.Biol Psychiatry, vol. 59, no. 6, Mar. 2006, pp. 523–29. Pubmed, doi:10.1016/j.biopsych.2005.08.007.
Tupler LA, De Bellis MD. Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder. Biol Psychiatry. 2006 Mar 15;59(6):523–529.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 15, 2006

Volume

59

Issue

6

Start / End Page

523 / 529

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Reference Values
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Internal-External Control
  • Image Processing, Computer-Assisted
  • Humans
  • Hippocampus
  • Female