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Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome.

Publication ,  Journal Article
Mintz, M; Rapaport, R; Oleske, JM; Connor, EM; Koenigsberger, MR; Denny, T; Epstein, LG
Published in: Am J Dis Child
July 1989

The cytokine tumor necrosis factor (TNF) was assayed in the sera (n = 31) and cerebrospinal fluid (n = 26) of children with acquired immunodeficiency syndrome, using a competitive radioimmunoassay. Elevated serum levels of TNF were found in 15 (79%) of 19 patients with progressive encephalopathy (PE), compared with 1 (8%) of 12 patients without neurologic involvement. There was a significant association of PE with elevated serum TNF levels. Conversely, of 16 patients with elevated serum TNF levels, 15 (94%) were found to have PE, and of 8 patients with serum TNF levels greater than 100 pg/ml, all 8 (100%) had PE. No association was found between cerebrospinal fluid levels of TNF and PE. Neither serum nor cerebrospinal fluid TNF levels correlated with the degree of cachexia. These data suggest that circulating TNF may be responsible for the myelin damage that occurs in human immunodeficiency virus type 1-associated PE.

Duke Scholars

Published In

Am J Dis Child

DOI

ISSN

0002-922X

Publication Date

July 1989

Volume

143

Issue

7

Start / End Page

771 / 774

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Infant
  • Humans
  • Child, Preschool
  • Child
  • Cachexia
  • Brain Diseases
  • Adolescent
  • Acquired Immunodeficiency Syndrome
 

Citation

APA
Chicago
ICMJE
MLA
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Mintz, M., Rapaport, R., Oleske, J. M., Connor, E. M., Koenigsberger, M. R., Denny, T., & Epstein, L. G. (1989). Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome. Am J Dis Child, 143(7), 771–774. https://doi.org/10.1001/archpedi.1989.02150190021012
Mintz, M., R. Rapaport, J. M. Oleske, E. M. Connor, M. R. Koenigsberger, T. Denny, and L. G. Epstein. “Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome.Am J Dis Child 143, no. 7 (July 1989): 771–74. https://doi.org/10.1001/archpedi.1989.02150190021012.
Mintz M, Rapaport R, Oleske JM, Connor EM, Koenigsberger MR, Denny T, et al. Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome. Am J Dis Child. 1989 Jul;143(7):771–4.
Mintz, M., et al. “Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome.Am J Dis Child, vol. 143, no. 7, July 1989, pp. 771–74. Pubmed, doi:10.1001/archpedi.1989.02150190021012.
Mintz M, Rapaport R, Oleske JM, Connor EM, Koenigsberger MR, Denny T, Epstein LG. Elevated serum levels of tumor necrosis factor are associated with progressive encephalopathy in children with acquired immunodeficiency syndrome. Am J Dis Child. 1989 Jul;143(7):771–774.

Published In

Am J Dis Child

DOI

ISSN

0002-922X

Publication Date

July 1989

Volume

143

Issue

7

Start / End Page

771 / 774

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Infant
  • Humans
  • Child, Preschool
  • Child
  • Cachexia
  • Brain Diseases
  • Adolescent
  • Acquired Immunodeficiency Syndrome