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Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy.

Publication ,  Journal Article
Peters, KB; Coyle, TE; Vredenburgh, JJ; Desjardins, A; Friedman, HS; Reardon, DA
Published in: J Neurooncol
January 2011

Striae distensae (stretch marks) are a common complication seen in patients on chronic corticosteroid therapy. Under certain circumstances, primary brain tumor patients require chronic corticosteroid therapy and can suffer from striae distensae. Bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor-A (VEGF-A) is now more widely used for the treatment of primary brain tumors. In this paper, we present four cases of ulcerated striae distensae in primary brain tumor patients on concurrent corticosteroid and bevacizumab therapy. Because of bevacizumab's effects on wound healing and its recent accelerated approval for recurrent glioblastoma multiforme (GBM), the most common malignant primary brain tumor in adults, this novel skin complication should be considered in patients on concurrent corticosteroid and bevacizumab therapy.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

January 2011

Volume

101

Issue

1

Start / End Page

155 / 159

Location

United States

Related Subject Headings

  • Young Adult
  • Ulcer
  • Striae Distensae
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Glioma
  • Female
  • Dexamethasone
 

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Peters, K. B., Coyle, T. E., Vredenburgh, J. J., Desjardins, A., Friedman, H. S., & Reardon, D. A. (2011). Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy. J Neurooncol, 101(1), 155–159. https://doi.org/10.1007/s11060-010-0239-0
Peters, Katherine B., Thomas E. Coyle, James J. Vredenburgh, Annick Desjardins, Henry S. Friedman, and David A. Reardon. “Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy.J Neurooncol 101, no. 1 (January 2011): 155–59. https://doi.org/10.1007/s11060-010-0239-0.
Peters KB, Coyle TE, Vredenburgh JJ, Desjardins A, Friedman HS, Reardon DA. Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy. J Neurooncol. 2011 Jan;101(1):155–9.
Peters, Katherine B., et al. “Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy.J Neurooncol, vol. 101, no. 1, Jan. 2011, pp. 155–59. Pubmed, doi:10.1007/s11060-010-0239-0.
Peters KB, Coyle TE, Vredenburgh JJ, Desjardins A, Friedman HS, Reardon DA. Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy. J Neurooncol. 2011 Jan;101(1):155–159.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

January 2011

Volume

101

Issue

1

Start / End Page

155 / 159

Location

United States

Related Subject Headings

  • Young Adult
  • Ulcer
  • Striae Distensae
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Glioma
  • Female
  • Dexamethasone