Mechanisms of disease progression in NASH: new paradigms.
Publication
, Journal Article
Bohinc, BN; Diehl, AM
Published in: Clin Liver Dis
August 2012
The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and NASH progression shows that hedgehog (Hh) is reactivated after liver injury to assist in liver repair and regeneration. When the process of tissue repair and regeneration is prolonged or when Hh ligand and related genes are aberrantly regulated and excessive, tissue repair goes awry and NASH progresses to cirrhosis and hepatocellular carcinoma.
Duke Scholars
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Published In
Clin Liver Dis
DOI
EISSN
1557-8224
Publication Date
August 2012
Volume
16
Issue
3
Start / End Page
549 / 565
Location
United States
Related Subject Headings
- Risk Factors
- Rats
- Paracrine Communication
- Non-alcoholic Fatty Liver Disease
- Mice
- Liver Cirrhosis
- Liver
- Inflammation
- Humans
- Hepatic Stellate Cells
Citation
APA
Chicago
ICMJE
MLA
NLM
Bohinc, B. N., & Diehl, A. M. (2012). Mechanisms of disease progression in NASH: new paradigms. Clin Liver Dis, 16(3), 549–565. https://doi.org/10.1016/j.cld.2012.05.002
Bohinc, Brittany N., and Anna Mae Diehl. “Mechanisms of disease progression in NASH: new paradigms.” Clin Liver Dis 16, no. 3 (August 2012): 549–65. https://doi.org/10.1016/j.cld.2012.05.002.
Bohinc BN, Diehl AM. Mechanisms of disease progression in NASH: new paradigms. Clin Liver Dis. 2012 Aug;16(3):549–65.
Bohinc, Brittany N., and Anna Mae Diehl. “Mechanisms of disease progression in NASH: new paradigms.” Clin Liver Dis, vol. 16, no. 3, Aug. 2012, pp. 549–65. Pubmed, doi:10.1016/j.cld.2012.05.002.
Bohinc BN, Diehl AM. Mechanisms of disease progression in NASH: new paradigms. Clin Liver Dis. 2012 Aug;16(3):549–565.
Published In
Clin Liver Dis
DOI
EISSN
1557-8224
Publication Date
August 2012
Volume
16
Issue
3
Start / End Page
549 / 565
Location
United States
Related Subject Headings
- Risk Factors
- Rats
- Paracrine Communication
- Non-alcoholic Fatty Liver Disease
- Mice
- Liver Cirrhosis
- Liver
- Inflammation
- Humans
- Hepatic Stellate Cells