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Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines.

Publication ,  Journal Article
Diehl, AM
Published in: Am J Physiol Gastrointest Liver Physiol
January 2002

Macrophage products, such as cytokines, prostanoids, nitric oxide, and reactive oxygen intermediates, influence the function and viability of macrophages and neighboring cells. Given that the liver has one of the largest resident macrophage populations in the body, it is not surprising that hepatic macrophages [i.e., Kupffer cells (KC)] are involved in the pathogenesis of many kinds of liver disease. This review summarizes the abnormalities that have been demonstrated in bone marrow, peritoneal and hepatic macrophage of leptin-resistant (fa/fa) rats and leptin-deficient (ob/ob) mice, two animal models for nonalcoholic fatty liver disease (NAFLD). Evidence supports the concept that altered KC function influences the viability of other cells, such as lymphocytes and hepatocytes, in fatty livers, thereby contributing to the pathogenesis of NAFLD in animals with reduced leptin activity. Further work is needed to determine whether KC dysfunction is a component of more generalized mechanisms that lead to NAFLD.

Duke Scholars

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

January 2002

Volume

282

Issue

1

Start / End Page

G1 / G5

Location

United States

Related Subject Headings

  • Obesity
  • Macrophages
  • Kupffer Cells
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Cytokines
  • Animals
  • 3208 Medical physiology
  • 3202 Clinical sciences
  • 1116 Medical Physiology
 

Citation

APA
Chicago
ICMJE
MLA
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Diehl, A. M. (2002). Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines. Am J Physiol Gastrointest Liver Physiol, 282(1), G1–G5. https://doi.org/10.1152/ajpgi.00384.2001
Diehl, Anna Mae. “Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines.Am J Physiol Gastrointest Liver Physiol 282, no. 1 (January 2002): G1–5. https://doi.org/10.1152/ajpgi.00384.2001.
Diehl, Anna Mae. “Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines.Am J Physiol Gastrointest Liver Physiol, vol. 282, no. 1, Jan. 2002, pp. G1–5. Pubmed, doi:10.1152/ajpgi.00384.2001.

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

January 2002

Volume

282

Issue

1

Start / End Page

G1 / G5

Location

United States

Related Subject Headings

  • Obesity
  • Macrophages
  • Kupffer Cells
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Cytokines
  • Animals
  • 3208 Medical physiology
  • 3202 Clinical sciences
  • 1116 Medical Physiology