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Cytokines and the molecular mechanisms of alcoholic liver disease.

Publication ,  Journal Article
Diehl, AM
Published in: Alcohol Clin Exp Res
September 1999

This manuscript was given as a plenary lecture at the annual meeting of the Research Society on Alcoholism in July of 1999. It describes the general mechanisms by which tumor necrosis factor (TNF) alpha, an injury-related cytokine, promotes liver regeneration and then details how TNF-initiated hepatotrophic signals are inhibited by chronic ethanol consumption. There is evidence that chronic ethanol exposure impairs the TNF-dependent activation of stress-activated protein kinases and some of their targets, including the growth-stimulatory DNA binding protein, c-Jun. Ethanol exposure also prevents TNF from activating the redox-sensitive transcription factor, NF kappa B, in regenerating hepatocytes. These effects are followed by decreased hepatocyte proliferation, as well as by impaired induction of TNF-regulated survival factors, such as Bcl-xL, in the liver. Thus, chronic ethanol consumption may damage the liver by inhibiting the hepatotrophic and hepatoprotective actions of TNFalpha and other growth-regulatory cytokines.

Duke Scholars

Published In

Alcohol Clin Exp Res

ISSN

0145-6008

Publication Date

September 1999

Volume

23

Issue

9

Start / End Page

1419 / 1424

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Substance Abuse
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Ethanol
  • Cytokines
  • Central Nervous System Depressants
  • Apoptosis
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (1999). Cytokines and the molecular mechanisms of alcoholic liver disease. Alcohol Clin Exp Res, 23(9), 1419–1424.
Diehl, A. M. “Cytokines and the molecular mechanisms of alcoholic liver disease.Alcohol Clin Exp Res 23, no. 9 (September 1999): 1419–24.
Diehl AM. Cytokines and the molecular mechanisms of alcoholic liver disease. Alcohol Clin Exp Res. 1999 Sep;23(9):1419–24.
Diehl, A. M. “Cytokines and the molecular mechanisms of alcoholic liver disease.Alcohol Clin Exp Res, vol. 23, no. 9, Sept. 1999, pp. 1419–24.
Diehl AM. Cytokines and the molecular mechanisms of alcoholic liver disease. Alcohol Clin Exp Res. 1999 Sep;23(9):1419–1424.
Journal cover image

Published In

Alcohol Clin Exp Res

ISSN

0145-6008

Publication Date

September 1999

Volume

23

Issue

9

Start / End Page

1419 / 1424

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Substance Abuse
  • Liver Diseases, Alcoholic
  • Liver
  • Humans
  • Ethanol
  • Cytokines
  • Central Nervous System Depressants
  • Apoptosis
  • Animals