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Effect of cardiac cycle on ultrasound assessment of endothelial function.

Publication ,  Journal Article
Chuang, ML; Douglas, PS; Bisinov, EA; Stein, JH
Published in: Vasc Med
May 2002

To investigate the effects of non-ECG-triggered imaging during ultrasound studies of endothelial function, brachial artery diameters were measured throughout the cardiac cycle at rest, during reactive hyperemia, and after administration of nitroglycerin. R-wave-triggered imaging using a 7.5-MHz ultrasound transducer with acquisition every 41.7-66.7 ms was performed in 24 subjects. Cardiac cycle-related variation was computed as the maximum per cent change from the end-diastolic diameter. The range of possible errors in flow-mediated dilation (FMD) and nitroglycerin-mediated vasodilation that may result from ignoring cyclic variations in diameter was determined for each condition. True FMD, true nitroglycerin-mediated vasodilation, and the maximum and minimum values that could be erroneously calculated for FMD if timing was ignored all differed dramatically (p < 0.05). The range of apparent FMD values that could be measured was nearly three times the true FMD value. Ignoring temporal position within the cardiac cycle artifactually increased calculated FMD into the normal range, despite truly impaired FMD. Peak arterial dilation occurred before end-systole and greater baseline vessel compliance was associated with greater FMD. Brachial arterial diameters vary significantly throughout the cardiac cycle. The magnitude of this variation is similar to the arterial dilation induced by reactive hyperemia and nitroglycerin, making ECG-triggered imaging mandatory for accurate and reproducible clinical and research measurements of artery diameters and FMD. Measurement of diameters at end-diastole may be preferred to other time-points in the cardiac cycle.

Duke Scholars

Published In

Vasc Med

DOI

ISSN

1358-863X

Publication Date

May 2002

Volume

7

Issue

2

Start / End Page

103 / 108

Location

England

Related Subject Headings

  • Wisconsin
  • Ventricular Function, Left
  • Vasodilator Agents
  • Vasodilation
  • Ultrasonography, Interventional
  • Systole
  • Stroke Volume
  • Prospective Studies
  • Predictive Value of Tests
  • Observer Variation
 

Citation

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Chuang, M. L., Douglas, P. S., Bisinov, E. A., & Stein, J. H. (2002). Effect of cardiac cycle on ultrasound assessment of endothelial function. Vasc Med, 7(2), 103–108. https://doi.org/10.1191/1358863x02vm425oa
Chuang, Michael L., Pamela S. Douglas, Elizabeth A. Bisinov, and James H. Stein. “Effect of cardiac cycle on ultrasound assessment of endothelial function.Vasc Med 7, no. 2 (May 2002): 103–8. https://doi.org/10.1191/1358863x02vm425oa.
Chuang ML, Douglas PS, Bisinov EA, Stein JH. Effect of cardiac cycle on ultrasound assessment of endothelial function. Vasc Med. 2002 May;7(2):103–8.
Chuang, Michael L., et al. “Effect of cardiac cycle on ultrasound assessment of endothelial function.Vasc Med, vol. 7, no. 2, May 2002, pp. 103–08. Pubmed, doi:10.1191/1358863x02vm425oa.
Chuang ML, Douglas PS, Bisinov EA, Stein JH. Effect of cardiac cycle on ultrasound assessment of endothelial function. Vasc Med. 2002 May;7(2):103–108.
Journal cover image

Published In

Vasc Med

DOI

ISSN

1358-863X

Publication Date

May 2002

Volume

7

Issue

2

Start / End Page

103 / 108

Location

England

Related Subject Headings

  • Wisconsin
  • Ventricular Function, Left
  • Vasodilator Agents
  • Vasodilation
  • Ultrasonography, Interventional
  • Systole
  • Stroke Volume
  • Prospective Studies
  • Predictive Value of Tests
  • Observer Variation