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Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.

Publication ,  Journal Article
Mirotsou, M; Jayawardena, TM; Schmeckpeper, J; Gnecchi, M; Dzau, VJ
Published in: J Mol Cell Cardiol
February 2011

Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured tissue by differentiating into specialized cardiac cell lineages and/or manipulating the cell and molecular mechanisms governing repair. Despite early reports describing engraftment and successful regeneration of cardiac tissue in animal models of heart failure, these events appear to be infrequent and yield too few new cardiomyocytes to account for the degree of improved cardiac function observed. Instead, mounting evidence suggests that stem cell mediated repair takes place via the release of paracrine factors into the surrounding tissue that subsequently direct a number of restorative processes including myocardial protection, neovascularization, cardiac remodeling, and differentiation. The potential for diverse stem cell populations to moderate many of the same processes as well as key paracrine factors and molecular pathways involved in stem cell-mediated cardiac repair will be discussed in this review. This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited".

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Published In

J Mol Cell Cardiol

DOI

EISSN

1095-8584

Publication Date

February 2011

Volume

50

Issue

2

Start / End Page

280 / 289

Location

England

Related Subject Headings

  • Stem Cells
  • Regeneration
  • Paracrine Communication
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Heart
  • Cell Differentiation
  • Cardiovascular System & Hematology
  • Bone Marrow Cells
  • Animals
 

Citation

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Mirotsou, M., Jayawardena, T. M., Schmeckpeper, J., Gnecchi, M., & Dzau, V. J. (2011). Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol, 50(2), 280–289. https://doi.org/10.1016/j.yjmcc.2010.08.005
Mirotsou, Maria, Tilanthi M. Jayawardena, Jeffrey Schmeckpeper, Massimiliano Gnecchi, and Victor J. Dzau. “Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.J Mol Cell Cardiol 50, no. 2 (February 2011): 280–89. https://doi.org/10.1016/j.yjmcc.2010.08.005.
Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol. 2011 Feb;50(2):280–9.
Mirotsou, Maria, et al. “Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.J Mol Cell Cardiol, vol. 50, no. 2, Feb. 2011, pp. 280–89. Pubmed, doi:10.1016/j.yjmcc.2010.08.005.
Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol. 2011 Feb;50(2):280–289.
Journal cover image

Published In

J Mol Cell Cardiol

DOI

EISSN

1095-8584

Publication Date

February 2011

Volume

50

Issue

2

Start / End Page

280 / 289

Location

England

Related Subject Headings

  • Stem Cells
  • Regeneration
  • Paracrine Communication
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Heart
  • Cell Differentiation
  • Cardiovascular System & Hematology
  • Bone Marrow Cells
  • Animals