Genetic engineering of mesenchymal stem cells and its application in human disease therapy.
The use of stem cells for tissue regeneration and repair is advancing both at the bench and bedside. Stem cells isolated from bone marrow are currently being tested for their therapeutic potential in a variety of clinical conditions including cardiovascular injury, kidney failure, cancer, and neurological and bone disorders. Despite the advantages, stem cell therapy is still limited by low survival, engraftment, and homing to damage area as well as inefficiencies in differentiating into fully functional tissues. Genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. This review presents the current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction. Advancements in other disease areas are also discussed.
Duke Scholars
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Related Subject Headings
- Renal Insufficiency
- Osteogenesis
- Nervous System Diseases
- Neoplasms
- Mesenchymal Stem Cells
- Mesenchymal Stem Cell Transplantation
- Humans
- Genetic Engineering
- Clinical Trials as Topic
- Cell Differentiation
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Renal Insufficiency
- Osteogenesis
- Nervous System Diseases
- Neoplasms
- Mesenchymal Stem Cells
- Mesenchymal Stem Cell Transplantation
- Humans
- Genetic Engineering
- Clinical Trials as Topic
- Cell Differentiation