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Molecular genetics and genomics of heart failure.

Publication ,  Journal Article
Liew, C-C; Dzau, VJ
Published in: Nat Rev Genet
November 2004
Published version (DOI) Link to item

Heart failure is a major disease burden worldwide, and its incidence continues to increase as premature deaths from other cardiovascular conditions decline. Although the overall molecular portrait of this multifactorial disease remains incomplete, molecular and genetic studies have implicated, in recent decades, various pathways and genes that participate in the pathophysiology of heart failure. Here, we highlight the current understanding of the molecular and genetic basis of heart failure and show how recently developed genomic tools are providing a new perspective on this complex disease.

Duke Scholars

Victor J. Dzau
Author Victor J. Dzau Medicine, Cardiology
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Published In

Nat Rev Genet

DOI

10.1038/nrg1470

ISSN

1471-0056

Publication Date

November 2004

Volume

5

Issue

11

Start / End Page

811 / 825

Location

England

Related Subject Headings

  • Humans
  • Genome, Human
  • Developmental Biology
  • Chromosome Mapping
  • Cardiac Output, Low
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology
  • 0604 Genetics
  • 0601 Biochemistry and Cell Biology
 

Citation

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Liew, C.-C., & Dzau, V. J. (2004). Molecular genetics and genomics of heart failure. Nat Rev Genet, 5(11), 811–825. https://doi.org/10.1038/nrg1470
Liew, Choong-Chin, and Victor J. Dzau. “Molecular genetics and genomics of heart failure.” Nat Rev Genet 5, no. 11 (November 2004): 811–25. https://doi.org/10.1038/nrg1470.
Liew C-C, Dzau VJ. Molecular genetics and genomics of heart failure. Nat Rev Genet. 2004 Nov;5(11):811–25.
Liew, Choong-Chin, and Victor J. Dzau. “Molecular genetics and genomics of heart failure.” Nat Rev Genet, vol. 5, no. 11, Nov. 2004, pp. 811–25. Pubmed, doi:10.1038/nrg1470.
Liew C-C, Dzau VJ. Molecular genetics and genomics of heart failure. Nat Rev Genet. 2004 Nov;5(11):811–825.

Published In

Nat Rev Genet

DOI

10.1038/nrg1470

ISSN

1471-0056

Publication Date

November 2004

Volume

5

Issue

11

Start / End Page

811 / 825

Location

England

Related Subject Headings

  • Humans
  • Genome, Human
  • Developmental Biology
  • Chromosome Mapping
  • Cardiac Output, Low
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology
  • 0604 Genetics
  • 0601 Biochemistry and Cell Biology