A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
Publication
, Journal Article
Ranade, K; Hinds, D; Hsiung, CA; Chuang, L-M; Chang, M-S; Chen, Y-T; Pesich, R; Hebert, J; Chen, Y-DI; Dzau, V; Olshen, R; Curb, D; Cox, DR ...
Published in: Am J Hypertens
February 2003
BACKGROUND: Our understanding of genes that predispose to essential hypertension is poor. METHODS: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). RESULTS: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. CONCLUSIONS: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
Duke Scholars
Published In
Am J Hypertens
DOI
ISSN
0895-7061
Publication Date
February 2003
Volume
16
Issue
2
Start / End Page
158 / 162
Location
United States
Related Subject Headings
- Middle Aged
- Lod Score
- Japan
- Hypertension
- Humans
- Genome, Human
- Genetic Predisposition to Disease
- Chromosomes, Human, Pair 10
- Chromosome Mapping
- China
Citation
APA
Chicago
ICMJE
MLA
NLM
Ranade, K., Hinds, D., Hsiung, C. A., Chuang, L.-M., Chang, M.-S., Chen, Y.-T., … Risch, N. (2003). A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Am J Hypertens, 16(2), 158–162. https://doi.org/10.1016/s0895-7061(02)03245-4
Ranade, Koustubh, David Hinds, Chao Agnes Hsiung, Lee-Ming Chuang, Mau-Song Chang, Ying-Tsung Chen, Robert Pesich, et al. “A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.” Am J Hypertens 16, no. 2 (February 2003): 158–62. https://doi.org/10.1016/s0895-7061(02)03245-4.
Ranade K, Hinds D, Hsiung CA, Chuang L-M, Chang M-S, Chen Y-T, et al. A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Am J Hypertens. 2003 Feb;16(2):158–62.
Ranade, Koustubh, et al. “A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.” Am J Hypertens, vol. 16, no. 2, Feb. 2003, pp. 158–62. Pubmed, doi:10.1016/s0895-7061(02)03245-4.
Ranade K, Hinds D, Hsiung CA, Chuang L-M, Chang M-S, Chen Y-T, Pesich R, Hebert J, Chen Y-DI, Dzau V, Olshen R, Curb D, Botstein D, Cox DR, Risch N. A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Am J Hypertens. 2003 Feb;16(2):158–162.
Published In
Am J Hypertens
DOI
ISSN
0895-7061
Publication Date
February 2003
Volume
16
Issue
2
Start / End Page
158 / 162
Location
United States
Related Subject Headings
- Middle Aged
- Lod Score
- Japan
- Hypertension
- Humans
- Genome, Human
- Genetic Predisposition to Disease
- Chromosomes, Human, Pair 10
- Chromosome Mapping
- China