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Gene therapy for human bypass grafts.

Publication ,  Journal Article
Mangi, AA; Dzau, VJ
Published in: Ann Med
April 2001

Autologous saphenous vein is the conduit of choice for the bypass of arterial occlusive disease, be it in the peripheral arterial tree or in the coronary system. This technique is limited by primary graft failure rates approaching 20% in the first year for peripheral arterial disease and 50% at 10 years for coronary artery bypass grafting. The PREVENT trial describes a novel, safe and effective means of ex vivo transfection of harvested vein grafts with an E2F decoy oligonucleotide, with 70-74% decreases in the level of proliferating cell nuclear antigen (PCNA) and c-myc mRNA expressed by the smooth muscle cells in the vein. This translated into a statistically significant reduction in primary graft failure when used to bypass peripheral arterial occlusions in a high-risk human patient population.

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Published In

Ann Med

DOI

ISSN

0785-3890

Publication Date

April 2001

Volume

33

Issue

3

Start / End Page

153 / 155

Location

England

Related Subject Headings

  • Oligonucleotides
  • Male
  • In Vitro Techniques
  • Humans
  • Genetic Therapy
  • Female
  • Coronary Disease
  • Coronary Artery Bypass
  • Cardiovascular System & Hematology
  • Animals
 

Citation

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Mangi, A. A., & Dzau, V. J. (2001). Gene therapy for human bypass grafts. Ann Med, 33(3), 153–155. https://doi.org/10.3109/07853890109002071
Mangi, A. A., and V. J. Dzau. “Gene therapy for human bypass grafts.Ann Med 33, no. 3 (April 2001): 153–55. https://doi.org/10.3109/07853890109002071.
Mangi AA, Dzau VJ. Gene therapy for human bypass grafts. Ann Med. 2001 Apr;33(3):153–5.
Mangi, A. A., and V. J. Dzau. “Gene therapy for human bypass grafts.Ann Med, vol. 33, no. 3, Apr. 2001, pp. 153–55. Pubmed, doi:10.3109/07853890109002071.
Mangi AA, Dzau VJ. Gene therapy for human bypass grafts. Ann Med. 2001 Apr;33(3):153–155.
Journal cover image

Published In

Ann Med

DOI

ISSN

0785-3890

Publication Date

April 2001

Volume

33

Issue

3

Start / End Page

153 / 155

Location

England

Related Subject Headings

  • Oligonucleotides
  • Male
  • In Vitro Techniques
  • Humans
  • Genetic Therapy
  • Female
  • Coronary Disease
  • Coronary Artery Bypass
  • Cardiovascular System & Hematology
  • Animals