Skip to main content
Journal cover image

Differential effects of antihypertensive agents in experimental and human atherosclerosis.

Publication ,  Journal Article
Omoigui, N; Dzau, VJ
Published in: Am J Hypertens
March 1993

The association between hypertension and atherosclerosis is complex, incorporating endothelial dysfunction, abnormalities of insulin and lipid metabolism, altered vascular biology, and impaired arterial compliance. Results of experimental and human studies suggest that there is heterogeneity in the manifestations of disease and responses to therapy among different animal species, vascular territories, and individual patients. Antihypertensive therapy requires the careful selection of specific agents that reduce blood pressure and preferentially and positively modulate the synergistic interaction of the many facets of disease, with the goal of preventing or regressing atherosclerosis. Angiotensin-converting enzyme (ACE) inhibitors, calcium antagonists, and alpha-blockers appear to hold the greatest promise in this regard.

Duke Scholars

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

March 1993

Volume

6

Issue

3 Pt 2

Start / End Page

30S / 39S

Location

United States

Related Subject Headings

  • Risk Factors
  • Male
  • Lipids
  • Hypertension
  • Humans
  • Female
  • Coronary Disease
  • Cardiovascular System & Hematology
  • Arteriosclerosis
  • Arteries
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Omoigui, N., & Dzau, V. J. (1993). Differential effects of antihypertensive agents in experimental and human atherosclerosis. Am J Hypertens, 6(3 Pt 2), 30S-39S. https://doi.org/10.1093/ajh/6.3.30s
Omoigui, N., and V. J. Dzau. “Differential effects of antihypertensive agents in experimental and human atherosclerosis.Am J Hypertens 6, no. 3 Pt 2 (March 1993): 30S-39S. https://doi.org/10.1093/ajh/6.3.30s.
Omoigui N, Dzau VJ. Differential effects of antihypertensive agents in experimental and human atherosclerosis. Am J Hypertens. 1993 Mar;6(3 Pt 2):30S-39S.
Omoigui, N., and V. J. Dzau. “Differential effects of antihypertensive agents in experimental and human atherosclerosis.Am J Hypertens, vol. 6, no. 3 Pt 2, Mar. 1993, pp. 30S-39S. Pubmed, doi:10.1093/ajh/6.3.30s.
Omoigui N, Dzau VJ. Differential effects of antihypertensive agents in experimental and human atherosclerosis. Am J Hypertens. 1993 Mar;6(3 Pt 2):30S-39S.
Journal cover image

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

March 1993

Volume

6

Issue

3 Pt 2

Start / End Page

30S / 39S

Location

United States

Related Subject Headings

  • Risk Factors
  • Male
  • Lipids
  • Hypertension
  • Humans
  • Female
  • Coronary Disease
  • Cardiovascular System & Hematology
  • Arteriosclerosis
  • Arteries