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The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes.

Publication ,  Journal Article
Dzau, VJ
Published in: Curr Opin Nephrol Hypertens
January 1993

Structural changes of the heart and blood vessels participate in the long-term regulation of the cardiovascular system. In hypertension and myocardial dysfunction, the adaptive process of cardiac and vascular remodeling may contribute to the pathophysiology and complications of these diseases. Recent investigations have enhanced our understanding of the cellular and molecular biology of vascular smooth muscle and cardiac myocyte growth. Mechanical and neurohormonal factors can independently stimulate hypertrophy-hyperplasia in vascular and cardiac myocytes. Increased pressure-stretch of cardiac myocyte and vascular smooth muscle cells can activate protooncogene expressions that may mediate the growth response. Vasoactive substances also regulate cardiovascular growth. In general, endogenous vasoconstrictors (eg, angiotensin, endothelin) act as growth promoters, and endogenous vasodilators (eg, nitric oxide, prostacyclin, atrial natriuretic peptide) act as growth inhibitors of vascular smooth muscle and, possibly, cardiac myocytes. Recent data have demonstrated that the vasoconstrictive agents, such as angiotensin, activate protooncogenes and autocrine growth factors that mediate vascular growth. Furthermore, the development of vascular hypertrophy versus hyperplasia is dependent on the relative activation of endogenous proliferative growth factor (eg, platelet-derived growth factor, basic fibroblast growth factor) versus antiproliferative factor (eg, transforming growth factor-beta) by the growth stimulus. Taken together, these data demonstrate that complex interactions of local mediators, which participate in the pathophysiology of cardiovascular diseases, control cardiovascular growth.

Duke Scholars

Published In

Curr Opin Nephrol Hypertens

DOI

ISSN

1062-4821

Publication Date

January 1993

Volume

2

Issue

1

Start / End Page

27 / 32

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Myocardium
  • Muscle, Smooth, Vascular
  • Muscle Development
  • Hypertension
  • Humans
  • Hormones
  • Heart
  • Animals
  • 3202 Clinical sciences
 

Citation

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Dzau, V. J. (1993). The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes. Curr Opin Nephrol Hypertens, 2(1), 27–32. https://doi.org/10.1097/00041552-199301000-00004
Dzau, V. J. “The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes.Curr Opin Nephrol Hypertens 2, no. 1 (January 1993): 27–32. https://doi.org/10.1097/00041552-199301000-00004.
Dzau, V. J. “The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes.Curr Opin Nephrol Hypertens, vol. 2, no. 1, Jan. 1993, pp. 27–32. Pubmed, doi:10.1097/00041552-199301000-00004.

Published In

Curr Opin Nephrol Hypertens

DOI

ISSN

1062-4821

Publication Date

January 1993

Volume

2

Issue

1

Start / End Page

27 / 32

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Myocardium
  • Muscle, Smooth, Vascular
  • Muscle Development
  • Hypertension
  • Humans
  • Hormones
  • Heart
  • Animals
  • 3202 Clinical sciences