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Tissue renin-angiotensin system in myocardial hypertrophy and failure.

Publication ,  Journal Article
Dzau, VJ
Published in: Arch Intern Med
April 26, 1993

The renin-angiotensin system traditionally has been conceived as a neuroendocrine system functioning in the circulation. Recent research has confirmed the existence of autocrine/paracrine tissue renin-angiotensin systems present and functioning at multiple sites, including cardiac, vascular, and renal tissues, which contain the majority of angiotensin-converting enzyme in the body. It appears that the circulating renin-angiotensin system is activated acutely to maintain homeostasis and is then turned off at cardiovascular compensation, while the tissue renin-angiotensin systems exert long-term actions that affect cardiovascular function and structure, which may play a pathophysiological role in congestive heart failure, hypertension, and vascular disease and influence the response to therapy with angiotensin-converting enzyme-inhibiting agents.

Duke Scholars

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

April 26, 1993

Volume

153

Issue

8

Start / End Page

937 / 942

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Peptidyl-Dipeptidase A
  • Humans
  • Heart Failure
  • General & Internal Medicine
  • Cardiomegaly
  • Animals
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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ICMJE
MLA
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Dzau, V. J. (1993). Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med, 153(8), 937–942.
Dzau, V. J. “Tissue renin-angiotensin system in myocardial hypertrophy and failure.Arch Intern Med 153, no. 8 (April 26, 1993): 937–42.
Dzau VJ. Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med. 1993 Apr 26;153(8):937–42.
Dzau, V. J. “Tissue renin-angiotensin system in myocardial hypertrophy and failure.Arch Intern Med, vol. 153, no. 8, Apr. 1993, pp. 937–42.
Dzau VJ. Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Intern Med. 1993 Apr 26;153(8):937–942.

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

April 26, 1993

Volume

153

Issue

8

Start / End Page

937 / 942

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Peptidyl-Dipeptidase A
  • Humans
  • Heart Failure
  • General & Internal Medicine
  • Cardiomegaly
  • Animals
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences