Tissue renin-angiotensin system in myocardial hypertrophy and failure.
The renin-angiotensin system traditionally has been conceived as a neuroendocrine system functioning in the circulation. Recent research has confirmed the existence of autocrine/paracrine tissue renin-angiotensin systems present and functioning at multiple sites, including cardiac, vascular, and renal tissues, which contain the majority of angiotensin-converting enzyme in the body. It appears that the circulating renin-angiotensin system is activated acutely to maintain homeostasis and is then turned off at cardiovascular compensation, while the tissue renin-angiotensin systems exert long-term actions that affect cardiovascular function and structure, which may play a pathophysiological role in congestive heart failure, hypertension, and vascular disease and influence the response to therapy with angiotensin-converting enzyme-inhibiting agents.
Duke Scholars
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Related Subject Headings
- Renin-Angiotensin System
- Peptidyl-Dipeptidase A
- Humans
- Heart Failure
- General & Internal Medicine
- Cardiomegaly
- Animals
- 3202 Clinical sciences
- 11 Medical and Health Sciences
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Renin-Angiotensin System
- Peptidyl-Dipeptidase A
- Humans
- Heart Failure
- General & Internal Medicine
- Cardiomegaly
- Animals
- 3202 Clinical sciences
- 11 Medical and Health Sciences