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Local contractile and growth modulators in the myocardium.

Publication ,  Journal Article
Dzau, VJ
Published in: Clin Cardiol
May 1993

Symptomatic congestive heart failure is the culmination of a process that evolves over many years. The long preclinical, or "incubation," period is the setting for a broad range of so-called local activities, including those involved in myocardial remodeling. Growth factors, cytokines, and vasoactive substances are central to this dynamic process, as are different populations of myocardial and circulating cells. The effects of angiotensin, endothelin, endothelium-derived relaxing factor, transforming growth factor-beta, and platelet-derived growth factor on myocardial structure, contractile function, and blood flow are outlined. The mechanisms involved in the activation of interleukin-1 and of tumor necrosis factor are examined within the context of the pathologic process.

Duke Scholars

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

May 1993

Volume

16

Issue

5 Suppl 2

Start / End Page

II5 / II9

Location

United States

Related Subject Headings

  • Myocardium
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • Heart
  • Growth Substances
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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MLA
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Dzau, V. J. (1993). Local contractile and growth modulators in the myocardium. Clin Cardiol, 16(5 Suppl 2), II5–II9. https://doi.org/10.1002/clc.4960161403
Dzau, V. J. “Local contractile and growth modulators in the myocardium.Clin Cardiol 16, no. 5 Suppl 2 (May 1993): II5–9. https://doi.org/10.1002/clc.4960161403.
Dzau VJ. Local contractile and growth modulators in the myocardium. Clin Cardiol. 1993 May;16(5 Suppl 2):II5–9.
Dzau, V. J. “Local contractile and growth modulators in the myocardium.Clin Cardiol, vol. 16, no. 5 Suppl 2, May 1993, pp. II5–9. Pubmed, doi:10.1002/clc.4960161403.
Dzau VJ. Local contractile and growth modulators in the myocardium. Clin Cardiol. 1993 May;16(5 Suppl 2):II5–II9.

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

May 1993

Volume

16

Issue

5 Suppl 2

Start / End Page

II5 / II9

Location

United States

Related Subject Headings

  • Myocardium
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • Heart
  • Growth Substances
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology