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Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns

Publication ,  Journal Article
Edwards, G; Shane Hutson, M; Hauger, S; Kozub, J; Shen, J; Shieh, C; Topadze, K; Joos, K
Published in: Proceedings of SPIE-The International Society for Optical Engineering
January 1, 2002

We have investigated the experimental consequences of two picosecond infrared lasers, both tuned to 6.45 μm and focused on ocular tissue. The exposure conditions were comparable, other than pulse repetition rate, where an optical parametric oscillator/amplifier laser (OPA) system operates at a kilohertz and the Mark-III FEL at 3 gigahertz. In both cases, the peak intensity was near 2×1014 W/m2 and the total delivered energy was approximately 125 mJ. The Mark-III consistently ablates tissue, while the OPA fails to ablate or to damage corneal tissue. In particular, there is no experimental evidence for protein denaturation due to OPA irradiation. We account for these observations in terms of a theoretical model based on thermal diffusion and threshold conditions for superheating and chemical kinetics. We comment on the relevance of tissue geometry.

Duke Scholars

Published In

Proceedings of SPIE-The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4633

Start / End Page

194 / 200
 

Citation

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Edwards, G., Shane Hutson, M., Hauger, S., Kozub, J., Shen, J., Shieh, C., … Joos, K. (2002). Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns. Proceedings of SPIE-The International Society for Optical Engineering, 4633, 194–200. https://doi.org/10.1117/12.461379
Edwards, G., M. Shane Hutson, S. Hauger, J. Kozub, J. Shen, C. Shieh, K. Topadze, and K. Joos. “Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns.” Proceedings of SPIE-The International Society for Optical Engineering 4633 (January 1, 2002): 194–200. https://doi.org/10.1117/12.461379.
Edwards G, Shane Hutson M, Hauger S, Kozub J, Shen J, Shieh C, et al. Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns. Proceedings of SPIE-The International Society for Optical Engineering. 2002 Jan 1;4633:194–200.
Edwards, G., et al. “Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns.” Proceedings of SPIE-The International Society for Optical Engineering, vol. 4633, Jan. 2002, pp. 194–200. Scopus, doi:10.1117/12.461379.
Edwards G, Shane Hutson M, Hauger S, Kozub J, Shen J, Shieh C, Topadze K, Joos K. Comparison of OPA and Mark-III FEL for tissue ablation at 6.45 microns. Proceedings of SPIE-The International Society for Optical Engineering. 2002 Jan 1;4633:194–200.

Published In

Proceedings of SPIE-The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4633

Start / End Page

194 / 200