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Infrared free electron laser-tissue interactions with human ocular tissues

Publication ,  Journal Article
Joos, KM; Shen, JH; Edwards, GS; Shetlar, DJ; Khoury, JM; Robinson, RD
Published in: Investigative Ophthalmology and Visual Science
February 15, 1996

Purpose. To utilize the tuning capability of the Vanderbilt University Free Electron Laser (FEL) to examine ocular laser-tissue interactions with novel infrared wavelengths for potential improvement of ophthalmic laser surgical procedures. Methods. Human cadaver eyes were placed in 7.5% dextran solution to normalize corneal thickness, and solution was injected intraocularly to achieve a physiologic intraocular pressure. Ocular tissues including cornea, iris, retina and optic nerve were lased at the 2.94 μm water absorbancy peak, 6.0 μm amide I band, 6.1 μm water absorbancy peak, 6.45 μm amide II band, and 7.7 μm delivered through a hollow waveguide. The Vanderbilt FEL produces 5 μs long macropulses at 10 Hz with each macropulse consisting of 1 ps micropulses at 3 GHz. Results. Histologic examination of corneal tissue showed the least amount of collateral damage (10 - 20 μm) with the 6.0 μm amide I band, while marked shrinkage occurred with the 7.7 μm wavelength. For optic nerve tissue, the least amount of collateral damage (0 μm visible) occurred at 6.1 μm water absorbancy peak and 6.45 μm amide II band, while the most damage (25 - 50 μm) was observed with the 7.7 μm wavelength. Conclusions. A hollow waveguide is capable of delivering useful infrared energy to ablate ocular tissues. Different tissues may have different optimal wavelengths for surgical laser procedures, and the tunable free election laser has the unique capability to investigate those potentially useful wavelengths.

Duke Scholars

Published In

Investigative Ophthalmology and Visual Science

ISSN

0146-0404

Publication Date

February 15, 1996

Volume

37

Issue

3

Related Subject Headings

  • Ophthalmology & Optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Joos, K. M., Shen, J. H., Edwards, G. S., Shetlar, D. J., Khoury, J. M., & Robinson, R. D. (1996). Infrared free electron laser-tissue interactions with human ocular tissues. Investigative Ophthalmology and Visual Science, 37(3).
Joos, K. M., J. H. Shen, G. S. Edwards, D. J. Shetlar, J. M. Khoury, and R. D. Robinson. “Infrared free electron laser-tissue interactions with human ocular tissues.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
Joos KM, Shen JH, Edwards GS, Shetlar DJ, Khoury JM, Robinson RD. Infrared free electron laser-tissue interactions with human ocular tissues. Investigative Ophthalmology and Visual Science. 1996 Feb 15;37(3).
Joos, K. M., et al. “Infrared free electron laser-tissue interactions with human ocular tissues.” Investigative Ophthalmology and Visual Science, vol. 37, no. 3, Feb. 1996.
Joos KM, Shen JH, Edwards GS, Shetlar DJ, Khoury JM, Robinson RD. Infrared free electron laser-tissue interactions with human ocular tissues. Investigative Ophthalmology and Visual Science. 1996 Feb 15;37(3).

Published In

Investigative Ophthalmology and Visual Science

ISSN

0146-0404

Publication Date

February 15, 1996

Volume

37

Issue

3

Related Subject Headings

  • Ophthalmology & Optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences