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Ring chromosomes and rDNA magnification in Drosophila.

Publication ,  Journal Article
Endow, SA; Komma, DJ; Atwood, KC
Published in: Genetics
December 1984

Tartof showed that ribosomal gene magnification in Drosophila was inhibited in a ring X chromosome. The present studies extend this observation by showing that ring X chromosomes are lost meiotically in male Drosophila undergoing ribosomal gene magnification as evidenced by the recovery of a lower number of ring-bearing progeny under magnifying conditions compared with nonmagnifying conditions. Associated with ring chromosome loss is a highly significant increase in the number of double-sized dicentric ring chromosomes in meiotic cells from magnifying males. These observations explain the failure of ring X chromosomes to magnify and imply that magnification in rod chromosomes occurs via a mechanism of unequal sister chromatid exchange. Our results support the hypothesis that the primary event of magnification is a sister chromatid exchange in the rDNA, that the frequency of sister strand exchanges is increased in magnifying flies, that a significant number of exchanges in magnifying flies occurs meiotically and that some of the exchanges are nonreciprocal. We have also found that autosomal mutations can affect both the frequency of abnormal ring structures and the ability of ring X chromosomes to magnify.

Duke Scholars

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

December 1984

Volume

108

Issue

4

Start / End Page

969 / 983

Location

United States

Related Subject Headings

  • Sister Chromatid Exchange
  • Ring Chromosomes
  • Models, Genetic
  • Meiosis
  • Male
  • Gene Amplification
  • Female
  • Drosophila melanogaster
  • Developmental Biology
  • DNA, Ribosomal
 

Citation

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Endow, S. A., Komma, D. J., & Atwood, K. C. (1984). Ring chromosomes and rDNA magnification in Drosophila. Genetics, 108(4), 969–983. https://doi.org/10.1093/genetics/108.4.969
Endow, S. A., D. J. Komma, and K. C. Atwood. “Ring chromosomes and rDNA magnification in Drosophila.Genetics 108, no. 4 (December 1984): 969–83. https://doi.org/10.1093/genetics/108.4.969.
Endow SA, Komma DJ, Atwood KC. Ring chromosomes and rDNA magnification in Drosophila. Genetics. 1984 Dec;108(4):969–83.
Endow, S. A., et al. “Ring chromosomes and rDNA magnification in Drosophila.Genetics, vol. 108, no. 4, Dec. 1984, pp. 969–83. Pubmed, doi:10.1093/genetics/108.4.969.
Endow SA, Komma DJ, Atwood KC. Ring chromosomes and rDNA magnification in Drosophila. Genetics. 1984 Dec;108(4):969–983.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

December 1984

Volume

108

Issue

4

Start / End Page

969 / 983

Location

United States

Related Subject Headings

  • Sister Chromatid Exchange
  • Ring Chromosomes
  • Models, Genetic
  • Meiosis
  • Male
  • Gene Amplification
  • Female
  • Drosophila melanogaster
  • Developmental Biology
  • DNA, Ribosomal