Skip to main content
Journal cover image

Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer.

Publication ,  Journal Article
Orloff, LA; Glenn, MG; Domb, AJ; Esclamado, RA
Published in: Surgery
May 1995

BACKGROUND: The effects of transmurally released heparin on the patency of microvenous anastomoses were studied by using a bioerodible polymer delivery system in a rat microvascular thrombosis model. METHODS: A polyanhydride carrier with heparin was wrapped around the outside of a highly thrombogenic venous inversion graft in 14 animals, and patency rates were compared with those of 17 control animals. RESULTS: Anastomotic patency was significantly greater in the groups treated with transmurally released heparin, measured both at 24 hours (86% versus 16%; p < 0.02) and at 7 days (86% versus 36%; p < 0.05) after operation. No significant complications occurred. CONCLUSIONS: Controlled release of heparin by transmural delivery is an effective and safe form of local antithrombotic therapy and may have applications both in microvascular and large vessel surgery.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

May 1995

Volume

117

Issue

5

Start / End Page

554 / 559

Location

United States

Related Subject Headings

  • Vascular Surgical Procedures
  • Vascular Patency
  • Thrombophlebitis
  • Surgery
  • Rats, Sprague-Dawley
  • Rats
  • Polymers
  • Microsurgery
  • Male
  • Intraoperative Complications
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Orloff, L. A., Glenn, M. G., Domb, A. J., & Esclamado, R. A. (1995). Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer. Surgery, 117(5), 554–559. https://doi.org/10.1016/s0039-6060(05)80255-7
Orloff, L. A., M. G. Glenn, A. J. Domb, and R. A. Esclamado. “Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer.Surgery 117, no. 5 (May 1995): 554–59. https://doi.org/10.1016/s0039-6060(05)80255-7.
Orloff, L. A., et al. “Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer.Surgery, vol. 117, no. 5, May 1995, pp. 554–59. Pubmed, doi:10.1016/s0039-6060(05)80255-7.
Orloff LA, Glenn MG, Domb AJ, Esclamado RA. Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer. Surgery. 1995 May;117(5):554–559.
Journal cover image

Published In

Surgery

DOI

ISSN

0039-6060

Publication Date

May 1995

Volume

117

Issue

5

Start / End Page

554 / 559

Location

United States

Related Subject Headings

  • Vascular Surgical Procedures
  • Vascular Patency
  • Thrombophlebitis
  • Surgery
  • Rats, Sprague-Dawley
  • Rats
  • Polymers
  • Microsurgery
  • Male
  • Intraoperative Complications