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Multiple relapses of Clostridium difficile-associated diarrhea in a cancer patient. Successful control with long-term cholestyramine therapy.

Publication ,  Journal Article
Moncino, MD; Falletta, JM
Published in: Am J Pediatr Hematol Oncol
November 1992

Clostridium difficile-associated diarrhea (CDAD) is caused by a toxin elaborated by the anaerobic organism Clostridium difficile. Although the vast majority of CDAD cases are now associated with antibiotic use, the administration of antineoplastic agents alone can result in clinical manifestations. While therapy with oral vancomycin is usually successful, one quarter of patients will relapse. We describe a 16-year-old girl with osteogenic sarcoma whose therapy was significantly complicated by multiple relapses of CDAD. All resulted in hospital admission. She failed several standard therapies for relapsed CDAD and was cured only after prolonged cholestyramine therapy. A subset of multiply relapsed CDAD patients may require prolonged therapy with cholestyramine to control the disease.

Duke Scholars

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

November 1992

Volume

14

Issue

4

Start / End Page

361 / 364

Location

United States

Related Subject Headings

  • Time Factors
  • Recurrence
  • Osteosarcoma
  • Humans
  • Female
  • Enterocolitis, Pseudomembranous
  • Diarrhea
  • Cholestyramine Resin
  • Bone Neoplasms
  • Agranulocytosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

November 1992

Volume

14

Issue

4

Start / End Page

361 / 364

Location

United States

Related Subject Headings

  • Time Factors
  • Recurrence
  • Osteosarcoma
  • Humans
  • Female
  • Enterocolitis, Pseudomembranous
  • Diarrhea
  • Cholestyramine Resin
  • Bone Neoplasms
  • Agranulocytosis