CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study.
Publication
, Journal Article
Komp, DM; Fernandez, CH; Falletta, JM; Ragab, AH; Humphrey, GB; Pullen, J; Moon, T; Shuster, J
Published in: Cancer
September 15, 1982
Children with acute lymphoblastic leukemia were randomized to one of two treatment options for CNS prophylaxis. All patients received intrathecal therapy over a one-year period with methotrexate, hydrocortisone and cytosine arabinoside. One-half of the patients also received 2400 rad cranial radiation over 2 1/2 weeks. There was no significant difference in CNS relapse rate, length of hematologic remission or survival between the two groups. No further CNS relapses have been observed for the last four years. CNS relapse was associated with subsequent disease recurrence in the 67% of patients.
Duke Scholars
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
September 15, 1982
Volume
50
Issue
6
Start / End Page
1031 / 1036
Location
United States
Related Subject Headings
- Radiotherapy Dosage
- Oncology & Carcinogenesis
- Neoplasm Staging
- Leukemia, Lymphoid
- Infant
- Humans
- Follow-Up Studies
- Drug Therapy, Combination
- Clinical Trials as Topic
- Child, Preschool
Citation
APA
Chicago
ICMJE
MLA
NLM
Komp, D. M., Fernandez, C. H., Falletta, J. M., Ragab, A. H., Humphrey, G. B., Pullen, J., … Shuster, J. (1982). CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study. Cancer, 50(6), 1031–1036. https://doi.org/10.1002/1097-0142(19820915)50:6<1031::aid-cncr2820500602>3.0.co;2-7
Komp, D. M., C. H. Fernandez, J. M. Falletta, A. H. Ragab, G. B. Humphrey, J. Pullen, T. Moon, and J. Shuster. “CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study.” Cancer 50, no. 6 (September 15, 1982): 1031–36. https://doi.org/10.1002/1097-0142(19820915)50:6<1031::aid-cncr2820500602>3.0.co;2-7.
Komp DM, Fernandez CH, Falletta JM, Ragab AH, Humphrey GB, Pullen J, et al. CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study. Cancer. 1982 Sep 15;50(6):1031–6.
Komp, D. M., et al. “CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study.” Cancer, vol. 50, no. 6, Sept. 1982, pp. 1031–36. Pubmed, doi:10.1002/1097-0142(19820915)50:6<1031::aid-cncr2820500602>3.0.co;2-7.
Komp DM, Fernandez CH, Falletta JM, Ragab AH, Humphrey GB, Pullen J, Moon T, Shuster J. CNS prophylaxis in acute lymphoblastic leukemia: comparison of two methods a Southwest Oncology Group study. Cancer. 1982 Sep 15;50(6):1031–1036.
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
September 15, 1982
Volume
50
Issue
6
Start / End Page
1031 / 1036
Location
United States
Related Subject Headings
- Radiotherapy Dosage
- Oncology & Carcinogenesis
- Neoplasm Staging
- Leukemia, Lymphoid
- Infant
- Humans
- Follow-Up Studies
- Drug Therapy, Combination
- Clinical Trials as Topic
- Child, Preschool