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Plasma epinephrine predicts fasting glucose in centrally obese African-American women.

Publication ,  Journal Article
Surwit, RS; Williams, RB; Lane, JD; Feinglos, MN; Kuhn, CM; Georgiades, A
Published in: Obesity (Silver Spring)
September 2010

The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. The aim of this article was to examine the interaction of plasma catecholamines and central adiposity on fasting and nonfasting glucose levels in two separate samples. In both studies, the women were healthy, nondiabetic of similar age. In addition, both studies assessed plasma epinephrine (EPI) and norepinephrine (NOREPI) levels collected at three time points. In study 1, catecholamines were measured during a standardized laboratory mental stress task and in study 2, they were measured during the initial phase (10 min) of an intravenous glucose tolerance test (IVGTT). Results from both studies revealed significant effects of EPI on fasting glucose in the obese women. In study 1, mean EPI levels were significantly related to fasting glucose in AA women with high trunk fat (beta = 0.60, P < 0.001). Because high BMI was associated with high trunk fat in women, we used BMI >30 as a proxy for high trunk fat (>32%) in study 2. In study 2, EPI response to the glucose bolus was a strong predictor of fasting glucose in AA women with BMI >30 (beta = 0.75, P < 0.003). We conclude that the effect of central adiposity on fasting glucose may be moderated by plasma EPI. This suggests that adrenal medullary activity could play a role in the pathophysiology of type 2 diabetes.

Duke Scholars

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

September 2010

Volume

18

Issue

9

Start / End Page

1683 / 1687

Location

United States

Related Subject Headings

  • Young Adult
  • Stress, Psychological
  • Regression Analysis
  • Obesity, Abdominal
  • Humans
  • Glucose Tolerance Test
  • Glucose Intolerance
  • Female
  • Fasting
  • Epinephrine
 

Citation

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Surwit, R. S., Williams, R. B., Lane, J. D., Feinglos, M. N., Kuhn, C. M., & Georgiades, A. (2010). Plasma epinephrine predicts fasting glucose in centrally obese African-American women. Obesity (Silver Spring), 18(9), 1683–1687. https://doi.org/10.1038/oby.2010.43
Surwit, Richard S., Redford B. Williams, James D. Lane, Mark N. Feinglos, Cynthia M. Kuhn, and Anastasia Georgiades. “Plasma epinephrine predicts fasting glucose in centrally obese African-American women.Obesity (Silver Spring) 18, no. 9 (September 2010): 1683–87. https://doi.org/10.1038/oby.2010.43.
Surwit RS, Williams RB, Lane JD, Feinglos MN, Kuhn CM, Georgiades A. Plasma epinephrine predicts fasting glucose in centrally obese African-American women. Obesity (Silver Spring). 2010 Sep;18(9):1683–7.
Surwit, Richard S., et al. “Plasma epinephrine predicts fasting glucose in centrally obese African-American women.Obesity (Silver Spring), vol. 18, no. 9, Sept. 2010, pp. 1683–87. Pubmed, doi:10.1038/oby.2010.43.
Surwit RS, Williams RB, Lane JD, Feinglos MN, Kuhn CM, Georgiades A. Plasma epinephrine predicts fasting glucose in centrally obese African-American women. Obesity (Silver Spring). 2010 Sep;18(9):1683–1687.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

September 2010

Volume

18

Issue

9

Start / End Page

1683 / 1687

Location

United States

Related Subject Headings

  • Young Adult
  • Stress, Psychological
  • Regression Analysis
  • Obesity, Abdominal
  • Humans
  • Glucose Tolerance Test
  • Glucose Intolerance
  • Female
  • Fasting
  • Epinephrine