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Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.

Publication ,  Journal Article
Rebuffé-Scrive, M; Surwit, R; Feinglos, M; Kuhn, C; Rodin, J
Published in: Metabolism
November 1993

It has been suggested that a genetic predisposition and an increased total fat mass, particularly a specific increase in visceral fat, contribute to the metabolic aberrations associated with human non-insulin-dependent diabetes mellitus (NIDDM). In this study, we investigated the interactions between genetic and dietary components on fat distribution and metabolism in two mouse strains, one genetically predisposed to NIDDM (BL/6) and one not (A/J), fed either a chow diet or a high-fat, high-simple carbohydrate (HFHSC) diet for 5 months. As expected, both strains of mice fed a HFHSC diet were heavier, had more fat in both the subcutaneous (inguinal [ING] and visceral (mesenteric [MES]) regions, and had larger fat cells and higher lipoprotein lipase (LPL) activities. The results of interactions between strain and diet showed important differences in fat distribution and metabolism between strains. In comparison with A/J mice, BL/6 mice fed a HFHSC diet developed hyperglycemia, hyperinsulinemia, and hypercholesterolemia, were heavier, had more overall fat, and particularly increased their MES adipose tissue. This increase in visceral fat mass was due to an increase in fat cell number. In contrast, BL/6 mice fed a chow diet had less overall fat, a smaller MES fat pad with smaller adipocytes, and lower LPL activity than A/J controls. Significant differences between BL/6 and A/J mice fed either a HFHSC or a chow diet were not observed in ING adipose tissue. These data suggest that in BL/6 mice, changes in the metabolic characteristics of visceral fat seem to be a specific characteristic associated with the genetic predisposition for NIDDM.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

November 1993

Volume

42

Issue

11

Start / End Page

1405 / 1409

Location

United States

Related Subject Headings

  • Mice, Inbred C57BL
  • Mice, Inbred A
  • Mice
  • Male
  • Lipoprotein Lipase
  • Insulin
  • Endocrinology & Metabolism
  • Disease Models, Animal
  • Dietary Fats
  • Diabetes Mellitus, Type 2
 

Citation

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ICMJE
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Rebuffé-Scrive, M., Surwit, R., Feinglos, M., Kuhn, C., & Rodin, J. (1993). Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism, 42(11), 1405–1409. https://doi.org/10.1016/0026-0495(93)90190-y
Rebuffé-Scrive, M., R. Surwit, M. Feinglos, C. Kuhn, and J. Rodin. “Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.Metabolism 42, no. 11 (November 1993): 1405–9. https://doi.org/10.1016/0026-0495(93)90190-y.
Rebuffé-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J. Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism. 1993 Nov;42(11):1405–9.
Rebuffé-Scrive, M., et al. “Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.Metabolism, vol. 42, no. 11, Nov. 1993, pp. 1405–09. Pubmed, doi:10.1016/0026-0495(93)90190-y.
Rebuffé-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J. Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism. 1993 Nov;42(11):1405–1409.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

November 1993

Volume

42

Issue

11

Start / End Page

1405 / 1409

Location

United States

Related Subject Headings

  • Mice, Inbred C57BL
  • Mice, Inbred A
  • Mice
  • Male
  • Lipoprotein Lipase
  • Insulin
  • Endocrinology & Metabolism
  • Disease Models, Animal
  • Dietary Fats
  • Diabetes Mellitus, Type 2