An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
Publication
, Journal Article
Urban, L; Aitken, PG; Friedman, A; Somjen, GG
Published in: Brain Res
May 7, 1990
Recordings were made from human hippocampal tissue surgically removed for treatment of epilepsy. In 70% of cases, an N-methyl-D-aspartate (NMDA) receptor-mediated component was present in excitatory synaptic input to gyrus dentatus. NMDA receptors are normally present, but do not participate in low-frequency synaptic transmission, in this region of the mammalian brain. These findings suggest that recruitment of normally dormant excitatory amino acid receptors may be a feature of the epileptic brain.
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Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
May 7, 1990
Volume
515
Issue
1-2
Start / End Page
319 / 322
Location
Netherlands
Related Subject Headings
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Piperazines
- Neurology & Neurosurgery
- In Vitro Techniques
- Humans
- Hippocampus
- Epilepsy
- Electric Stimulation
- Action Potentials
Citation
APA
Chicago
ICMJE
MLA
NLM
Urban, L., Aitken, P. G., Friedman, A., & Somjen, G. G. (1990). An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro. Brain Res, 515(1–2), 319–322. https://doi.org/10.1016/0006-8993(90)90615-i
Urban, L., P. G. Aitken, A. Friedman, and G. G. Somjen. “An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.” Brain Res 515, no. 1–2 (May 7, 1990): 319–22. https://doi.org/10.1016/0006-8993(90)90615-i.
Urban L, Aitken PG, Friedman A, Somjen GG. An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro. Brain Res. 1990 May 7;515(1–2):319–22.
Urban, L., et al. “An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.” Brain Res, vol. 515, no. 1–2, May 1990, pp. 319–22. Pubmed, doi:10.1016/0006-8993(90)90615-i.
Urban L, Aitken PG, Friedman A, Somjen GG. An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro. Brain Res. 1990 May 7;515(1–2):319–322.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
May 7, 1990
Volume
515
Issue
1-2
Start / End Page
319 / 322
Location
Netherlands
Related Subject Headings
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Piperazines
- Neurology & Neurosurgery
- In Vitro Techniques
- Humans
- Hippocampus
- Epilepsy
- Electric Stimulation
- Action Potentials