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Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab.

Publication ,  Journal Article
Wefel, JS; Cloughesy, T; Zazzali, JL; Zheng, M; Prados, M; Wen, PY; Mikkelsen, T; Schiff, D; Abrey, LE; Yung, WKA; Paleologos, N; Nicholas, MK ...
Published in: Neuro Oncol
June 2011

Neurocognitive decline is a frequent adverse effect of glioblastoma. Antitumor therapies that are efficacious, as measured by traditional endpoints such as objective response (OR) and progression-free survival (PFS), and have beneficial effects on neurocognitive function (NCF) are of clinical benefit to these patients. We evaluated neurocognitive changes across time in 167 patients with recurrent glioblastoma treated with bevacizumab-based therapy in BRAIN, a phase II, randomized, multicenter trial. All patients underwent MRI and neurocognitive testing at baseline and every 6 weeks thereafter. Memory, visuomotor scanning speed, and executive function were evaluated using the Hopkins Verbal Learning Test-Revised, the Trail Making Test, and the Controlled Oral Word Association test, respectively. NCF relative to baseline for patients with an OR, PFS >6 months, or disease progression was evaluated at time of OR, 24 weeks, and time of progression, respectively. For patients with an OR or PFS >6 months, median standardized test scores were examined from baseline to week 24. Most patients with an OR or PFS >6 months had poorer NCF performance compared to the general population at baseline and had improved or stable NCF at the time of response or at the 24-week assessment, respectively; most patients with progressive disease had neurocognitive decline at the time of progression. For patients with an OR or PFS >6 months, median standardized test scores were largely stable across the first 24 weeks on study. Neurocognitive testing was an objective, valid, and feasible method of monitoring NCF in patients with recurrent glioblastoma.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

June 2011

Volume

13

Issue

6

Start / End Page

660 / 668

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Survival Rate
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
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Wefel, J. S., Cloughesy, T., Zazzali, J. L., Zheng, M., Prados, M., Wen, P. Y., … Friedman, H. S. (2011). Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol, 13(6), 660–668. https://doi.org/10.1093/neuonc/nor024
Wefel, Jeffrey S., Timothy Cloughesy, James L. Zazzali, Maoxia Zheng, Michael Prados, Patrick Y. Wen, Tom Mikkelsen, et al. “Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab.Neuro Oncol 13, no. 6 (June 2011): 660–68. https://doi.org/10.1093/neuonc/nor024.
Wefel JS, Cloughesy T, Zazzali JL, Zheng M, Prados M, Wen PY, et al. Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol. 2011 Jun;13(6):660–8.
Wefel, Jeffrey S., et al. “Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab.Neuro Oncol, vol. 13, no. 6, June 2011, pp. 660–68. Pubmed, doi:10.1093/neuonc/nor024.
Wefel JS, Cloughesy T, Zazzali JL, Zheng M, Prados M, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WKA, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Das A, Friedman HS. Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol. 2011 Jun;13(6):660–668.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

June 2011

Volume

13

Issue

6

Start / End Page

660 / 668

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Survival Rate
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging