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MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences.

Publication ,  Journal Article
Tien, RD; Felsberg, GJ; Friedman, H; Brown, M; MacFall, J
Published in: AJR Am J Roentgenol
March 1994

OBJECTIVE: The purpose of this study was to evaluate the usefulness of diffusion-weighted echoplanar MR imaging in the examination of high-grade brain gliomas compared with that of conventional spin-echo (SE) or fast spin-echo (FSE) MR imaging. We hypothesize that diffusion-weighted MR imaging may enable us to differentiate various tumor components on the basis of differences in the diffusion of water. SUBJECTS AND METHODS: Conventional SE and FSE MR images were obtained in 10 patients with high-grade brain glioma. Diffusion-weighted echoplanar MR images were obtained with a head gradient coil capable of providing diffusion-weighted imaging along the cephalocaudal axis. Using SE and FSE MR images as a baseline, we evaluated the diffusion-weighted MR images for usefulness in distinguishing tumor components on the basis of differences in diffusion. RESULTS: Areas of tumor that showed significant enhancement on T1-weighted SE MR images obtained after injection of contrast material were markedly hyperintense on diffusion-weighted images and had a lower apparent diffusion coefficient (ADC) than the ADCs for nonenhancing tumor and peritumoral edema. Cystic or necrotic portions of tumor showed the most signal suppression on diffusion-weighted images and were associated with the highest ADCs. On T2-weighted FSE MR images, areas of hyperintensity observed in white matter oriented parallel to the direction of the diffusion gradient could be differentiated into two patterns on the basis of findings on diffusion-weighted images: areas that showed marked signal suppression with a higher ADC, most likely representing areas of predominantly peritumoral edema, and areas that showed a lesser degree of signal suppression with similar but slightly lower ADCs than those of edema, most likely representing areas of predominantly nonenhancing tumor. CONCLUSION: Diffusion-weighted echoplanar MR imaging is a useful technique for examining high-grade cerebral gliomas. It enabled us to differentiate various components of the tumor (e.g., enhancing, nonenhancing, cystic, or necrotic) and to distinguish areas of predominantly nonenhancing tumor from areas of predominantly peritumoral edema when the abnormality was located in the white matter aligned in the direction of the diffusion-weighted gradient. Diffusion-weighted echoplanar MR imaging appears to be a powerful tool in the characterization of brain neoplasms.

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Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

March 1994

Volume

162

Issue

3

Start / End Page

671 / 677

Location

United States

Related Subject Headings

  • Supratentorial Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Glioblastoma
  • Female
  • Echo-Planar Imaging
  • Brain
 

Citation

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Chicago
ICMJE
MLA
NLM
Tien, R. D., Felsberg, G. J., Friedman, H., Brown, M., & MacFall, J. (1994). MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol, 162(3), 671–677. https://doi.org/10.2214/ajr.162.3.8109520
Tien, R. D., G. J. Felsberg, H. Friedman, M. Brown, and J. MacFall. “MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences.AJR Am J Roentgenol 162, no. 3 (March 1994): 671–77. https://doi.org/10.2214/ajr.162.3.8109520.
Tien RD, Felsberg GJ, Friedman H, Brown M, MacFall J. MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol. 1994 Mar;162(3):671–7.
Tien, R. D., et al. “MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences.AJR Am J Roentgenol, vol. 162, no. 3, Mar. 1994, pp. 671–77. Pubmed, doi:10.2214/ajr.162.3.8109520.
Tien RD, Felsberg GJ, Friedman H, Brown M, MacFall J. MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol. 1994 Mar;162(3):671–677.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

March 1994

Volume

162

Issue

3

Start / End Page

671 / 677

Location

United States

Related Subject Headings

  • Supratentorial Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Glioblastoma
  • Female
  • Echo-Planar Imaging
  • Brain