Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.
Publication
, Journal Article
Davidian, M; Gallant, AR
Published in: J Pharmacokinet Biopharm
October 1992
The seminonparametric (SNP) method, popular in the econometrics literature, is proposed for use in population pharmacokinetic analysis. For data that can be described by the nonlinear mixed effects model, the method produces smooth nonparametric estimates of the entire random effects density and simultaneous estimates of fixed effects by maximum likelihood. A graphical model-building strategy based on the SNP method is described. The methods are illustrated by a population analysis of plasma levels in 136 patients undergoing oral quinidine therapy.
Duke Scholars
Published In
J Pharmacokinet Biopharm
DOI
ISSN
0090-466X
Publication Date
October 1992
Volume
20
Issue
5
Start / End Page
529 / 556
Location
United States
Related Subject Headings
- Software
- Quinidine
- Population
- Pharmacology & Pharmacy
- Pharmacokinetics
- Models, Biological
- Methods
- Mathematical Computing
- Male
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Davidian, M., & Gallant, A. R. (1992). Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm, 20(5), 529–556. https://doi.org/10.1007/BF01061470
Davidian, M., and A. R. Gallant. “Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.” J Pharmacokinet Biopharm 20, no. 5 (October 1992): 529–56. https://doi.org/10.1007/BF01061470.
Davidian M, Gallant AR. Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm. 1992 Oct;20(5):529–56.
Davidian, M., and A. R. Gallant. “Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.” J Pharmacokinet Biopharm, vol. 20, no. 5, Oct. 1992, pp. 529–56. Pubmed, doi:10.1007/BF01061470.
Davidian M, Gallant AR. Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm. 1992 Oct;20(5):529–556.
Published In
J Pharmacokinet Biopharm
DOI
ISSN
0090-466X
Publication Date
October 1992
Volume
20
Issue
5
Start / End Page
529 / 556
Location
United States
Related Subject Headings
- Software
- Quinidine
- Population
- Pharmacology & Pharmacy
- Pharmacokinetics
- Models, Biological
- Methods
- Mathematical Computing
- Male
- Humans