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Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.

Publication ,  Journal Article
Davidian, M; Gallant, AR
Published in: J Pharmacokinet Biopharm
October 1992

The seminonparametric (SNP) method, popular in the econometrics literature, is proposed for use in population pharmacokinetic analysis. For data that can be described by the nonlinear mixed effects model, the method produces smooth nonparametric estimates of the entire random effects density and simultaneous estimates of fixed effects by maximum likelihood. A graphical model-building strategy based on the SNP method is described. The methods are illustrated by a population analysis of plasma levels in 136 patients undergoing oral quinidine therapy.

Duke Scholars

Published In

J Pharmacokinet Biopharm

DOI

ISSN

0090-466X

Publication Date

October 1992

Volume

20

Issue

5

Start / End Page

529 / 556

Location

United States

Related Subject Headings

  • Software
  • Quinidine
  • Population
  • Pharmacology & Pharmacy
  • Pharmacokinetics
  • Models, Biological
  • Methods
  • Mathematical Computing
  • Male
  • Humans
 

Citation

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Davidian, M., & Gallant, A. R. (1992). Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm, 20(5), 529–556. https://doi.org/10.1007/BF01061470
Davidian, M., and A. R. Gallant. “Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.J Pharmacokinet Biopharm 20, no. 5 (October 1992): 529–56. https://doi.org/10.1007/BF01061470.
Davidian, M., and A. R. Gallant. “Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.J Pharmacokinet Biopharm, vol. 20, no. 5, Oct. 1992, pp. 529–56. Pubmed, doi:10.1007/BF01061470.
Davidian M, Gallant AR. Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm. 1992 Oct;20(5):529–556.

Published In

J Pharmacokinet Biopharm

DOI

ISSN

0090-466X

Publication Date

October 1992

Volume

20

Issue

5

Start / End Page

529 / 556

Location

United States

Related Subject Headings

  • Software
  • Quinidine
  • Population
  • Pharmacology & Pharmacy
  • Pharmacokinetics
  • Models, Biological
  • Methods
  • Mathematical Computing
  • Male
  • Humans