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Minor-drug-resistant HIV populations and treatment failure

Publication ,  Journal Article
Gao, F; Wang, D
Published in: Future Virology
May 1, 2007

Treatment efficacy in those infected with HIV is eventually compromised by the development of resistance to antiretroviral drugs. To delay resistance in patients it is critical to better understand drug-resistance mechanisms and to accurately detect drug-resistant mutations prior to treatment. Minor-drug-resistant viruses are present in chronically infected patients, treatment-failure patients and those recently infected with resistant viruses through transmission. They are often present at levels below 20%, therefore conventional genotypic and phenotypic assays cannot detect them. Accumulating data indicate that minor-resistant viruses that are present before treatment can lead to drug resistance and poor treatment responses in patients. Detailed characterization of such minor-resistant populations using highly sensitive assays may have a profound impact on the treatment of HIV-infected individuals. © 2007 Future Medicine Ltd.

Duke Scholars

Published In

Future Virology

DOI

ISSN

1746-0794

Publication Date

May 1, 2007

Volume

2

Issue

3

Start / End Page

293 / 302

Related Subject Headings

  • Virology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, F., & Wang, D. (2007). Minor-drug-resistant HIV populations and treatment failure. Future Virology, 2(3), 293–302. https://doi.org/10.2217/17460794.2.3.293
Gao, F., and D. Wang. “Minor-drug-resistant HIV populations and treatment failure.” Future Virology 2, no. 3 (May 1, 2007): 293–302. https://doi.org/10.2217/17460794.2.3.293.
Gao F, Wang D. Minor-drug-resistant HIV populations and treatment failure. Future Virology. 2007 May 1;2(3):293–302.
Gao, F., and D. Wang. “Minor-drug-resistant HIV populations and treatment failure.” Future Virology, vol. 2, no. 3, May 2007, pp. 293–302. Scopus, doi:10.2217/17460794.2.3.293.
Gao F, Wang D. Minor-drug-resistant HIV populations and treatment failure. Future Virology. 2007 May 1;2(3):293–302.
Journal cover image

Published In

Future Virology

DOI

ISSN

1746-0794

Publication Date

May 1, 2007

Volume

2

Issue

3

Start / End Page

293 / 302

Related Subject Headings

  • Virology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology