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[Protective effect of SNMC on mice with fulminant liver failure].

Publication ,  Journal Article
Chen, L-Y; Yang, B-S; Ma, Y-J; Bi, M-R; Gao, F
Published in: Zhonghua Gan Zang Bing Za Zhi
March 2005

OBJECTIVE: To investigate the protective effect of stronger neo-minophagen C (SNMC) on fulminant liver failure (FLF). METHODS: D-Gal N and LPS were injected once into the abdominal cavity of rats to establish an experimental model of FLF. The level of plasma ALT, Alb, TBil, TNFalpha, NO, ET-1, IL-6 and liver histopathology of the rats were examined. RESULTS: In the D-Gal N and LPS model of FLF, there was an obvious decline of plasma TNFalpha (F = 52.84), NO (F = 15.81), ET-1 (F = 15.68), IL-6 (F = 15.32) and there was less hepatic tissue damage in SNMC-treated groups using different doses (high dose, medium dose, low dose) and at different times (pre-protection, simultaneous protection, post-protection) compared with those not treated with SNMC. These results indicated that SNMC could be used to treat FLF. It was better to use a low dose of SNMC and use it at the same time as inducing the FLF. There were no differences in the results of those treated with SNMC of different dosages and treated at different times. CONCLUSION: SNMC can decrease the mortality of FLF by preventing hepatocyte apoptosis induced by D-Gal N and LPS and inhibit liver inflammation caused by all kinds of factors.

Duke Scholars

Published In

Zhonghua Gan Zang Bing Za Zhi

ISSN

1007-3418

Publication Date

March 2005

Volume

13

Issue

3

Start / End Page

209 / 212

Location

China

Related Subject Headings

  • Mice
  • Male
  • Liver Failure, Acute
  • Lipopolysaccharides
  • Glycyrrhizic Acid
  • Galactosamine
  • Female
  • Anti-Inflammatory Agents, Non-Steroidal
  • Animals
 

Citation

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Chen, L.-Y., Yang, B.-S., Ma, Y.-J., Bi, M.-R., & Gao, F. (2005). [Protective effect of SNMC on mice with fulminant liver failure]. Zhonghua Gan Zang Bing Za Zhi, 13(3), 209–212.
Chen, Li-yan, Bao-shan Yang, Ying-ji Ma, Man-ru Bi, and Feng Gao. “[Protective effect of SNMC on mice with fulminant liver failure].Zhonghua Gan Zang Bing Za Zhi 13, no. 3 (March 2005): 209–12.
Chen L-Y, Yang B-S, Ma Y-J, Bi M-R, Gao F. [Protective effect of SNMC on mice with fulminant liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2005 Mar;13(3):209–12.
Chen, Li-yan, et al. “[Protective effect of SNMC on mice with fulminant liver failure].Zhonghua Gan Zang Bing Za Zhi, vol. 13, no. 3, Mar. 2005, pp. 209–12.
Chen L-Y, Yang B-S, Ma Y-J, Bi M-R, Gao F. [Protective effect of SNMC on mice with fulminant liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2005 Mar;13(3):209–212.

Published In

Zhonghua Gan Zang Bing Za Zhi

ISSN

1007-3418

Publication Date

March 2005

Volume

13

Issue

3

Start / End Page

209 / 212

Location

China

Related Subject Headings

  • Mice
  • Male
  • Liver Failure, Acute
  • Lipopolysaccharides
  • Glycyrrhizic Acid
  • Galactosamine
  • Female
  • Anti-Inflammatory Agents, Non-Steroidal
  • Animals