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Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2).

Publication ,  Journal Article
Bibollet-Ruche, F; Gao, F; Bailes, E; Saragosti, S; Delaporte, E; Peeters, M; Shaw, GM; Hahn, BH; Sharp, PM
Published in: AIDS Res Hum Retroviruses
December 2004

Chimpanzees in west central Africa (Pan troglodytes troglodytes) are known to harbor simian immunodeficiency viruses (SIVcpzPtt) that represent the closest relatives of human immunodeficiency virus type 1 (HIV-1); however, the number of SIVcpzPtt strains that have been fully characterized is still limited. Here, we report the complete nucleotide sequence of SIVcpzGAB2, a virus originally identified in 1989 in a chimpanzee (P. t. troglodytes) from Gabon. Analysis of this sequence reveals that SIVcpzGAB2 is a member of the SIVcpzPtt group of viruses, but that it differs from other SIVcpzPtt strains by exhibiting a highly divergent Env V3 loop with an unusual crown (NLSPGTT) containing a canonical N-linked glycosylation site, an unpaired cysteine residue in Env V4, and two late (L) domain motifs (PTAP and YPSL) in Gag p6. Moreover, phylogenetic analyses indicate evidence of recombination during the early divergence of SIVcpzPtt strains; in particular, part of the pol gene sequence of SIVcpzGAB2 appears to be derived from a previously unidentified SIVcpz lineage ancestral to HIV-1 group O. These data indicate extensive diversity among naturally occurring SIVcpzPtt strains and provide new insight into the origin of HIV-1 group O.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

December 2004

Volume

20

Issue

12

Start / End Page

1377 / 1381

Location

United States

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Phylogeny
  • Pan troglodytes
  • Molecular Sequence Data
  • Genome, Viral
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bibollet-Ruche, F., Gao, F., Bailes, E., Saragosti, S., Delaporte, E., Peeters, M., … Sharp, P. M. (2004). Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2). AIDS Res Hum Retroviruses, 20(12), 1377–1381. https://doi.org/10.1089/aid.2004.20.1377
Bibollet-Ruche, Frederic, Feng Gao, Elizabeth Bailes, Sentob Saragosti, Eric Delaporte, Martine Peeters, George M. Shaw, Beatrice H. Hahn, and Paul M. Sharp. “Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2).AIDS Res Hum Retroviruses 20, no. 12 (December 2004): 1377–81. https://doi.org/10.1089/aid.2004.20.1377.
Bibollet-Ruche F, Gao F, Bailes E, Saragosti S, Delaporte E, Peeters M, et al. Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2). AIDS Res Hum Retroviruses. 2004 Dec;20(12):1377–81.
Bibollet-Ruche, Frederic, et al. “Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2).AIDS Res Hum Retroviruses, vol. 20, no. 12, Dec. 2004, pp. 1377–81. Pubmed, doi:10.1089/aid.2004.20.1377.
Bibollet-Ruche F, Gao F, Bailes E, Saragosti S, Delaporte E, Peeters M, Shaw GM, Hahn BH, Sharp PM. Complete genome analysis of one of the earliest SIVcpzPtt strains from Gabon (SIVcpzGAB2). AIDS Res Hum Retroviruses. 2004 Dec;20(12):1377–1381.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

December 2004

Volume

20

Issue

12

Start / End Page

1377 / 1381

Location

United States

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Phylogeny
  • Pan troglodytes
  • Molecular Sequence Data
  • Genome, Viral
  • Animals