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Diversity considerations in HIV-1 vaccine selection.

Publication ,  Journal Article
Gaschen, B; Taylor, J; Yusim, K; Foley, B; Gao, F; Lang, D; Novitsky, V; Haynes, B; Hahn, BH; Bhattacharya, T; Korber, B
Published in: Science
June 28, 2002

Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 28, 2002

Volume

296

Issue

5577

Start / End Page

2354 / 2360

Location

United States

Related Subject Headings

  • Phylogeny
  • Likelihood Functions
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antigens
  • HIV Antibodies
  • Genome, Viral
  • Genetic Variation
  • General Science & Technology
 

Citation

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Gaschen, B., Taylor, J., Yusim, K., Foley, B., Gao, F., Lang, D., … Korber, B. (2002). Diversity considerations in HIV-1 vaccine selection. Science, 296(5577), 2354–2360. https://doi.org/10.1126/science.1070441
Gaschen, Brian, Jesse Taylor, Karina Yusim, Brian Foley, Feng Gao, Dorothy Lang, Vladimir Novitsky, et al. “Diversity considerations in HIV-1 vaccine selection.Science 296, no. 5577 (June 28, 2002): 2354–60. https://doi.org/10.1126/science.1070441.
Gaschen B, Taylor J, Yusim K, Foley B, Gao F, Lang D, et al. Diversity considerations in HIV-1 vaccine selection. Science. 2002 Jun 28;296(5577):2354–60.
Gaschen, Brian, et al. “Diversity considerations in HIV-1 vaccine selection.Science, vol. 296, no. 5577, June 2002, pp. 2354–60. Pubmed, doi:10.1126/science.1070441.
Gaschen B, Taylor J, Yusim K, Foley B, Gao F, Lang D, Novitsky V, Haynes B, Hahn BH, Bhattacharya T, Korber B. Diversity considerations in HIV-1 vaccine selection. Science. 2002 Jun 28;296(5577):2354–2360.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 28, 2002

Volume

296

Issue

5577

Start / End Page

2354 / 2360

Location

United States

Related Subject Headings

  • Phylogeny
  • Likelihood Functions
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antigens
  • HIV Antibodies
  • Genome, Viral
  • Genetic Variation
  • General Science & Technology