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Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China.

Publication ,  Journal Article
McClutchan, FE; Carr, JK; Murphy, D; Piyasirisilp, S; Gao, F; Hahn, B; Yu, X-F; Beyrer, C; Birx, DL
Published in: AIDS Res Hum Retroviruses
October 10, 2002

Two different BC recombinant HIV-1 strains have arisen and begun to circulate among intravenous drug users in China. The recombinants are mostly subtype C with a few small subtype B segments. Additional full-genome sequences of the two recombinants, termed CRF07_BC and CRFO&_BC, are now available for analysis. Four CRF07_BC strains, including c54, 97CNU01, 98CN009, and a new strain CNGL-179, described here, and four CRF08_BC strains, including 97CNGX-6, 97CNGX-7, 97CNGX-9, and 98CN006, were compared for their recombination breakpoints by bootscanning and software for fine mapping of recombinants. The four CRF07_BC strains shared an identical recombination structure and the four CRF08_BC strains shared an identical, but different, recombination structure. The two CRFs share five precise subtype B/C boundaries, although although other segments differ between them, suggesting that they shared a common ancestor, itself a BC recombinant that separately "back-crossed" onto different subtype C strains. Both CRFs are broadly distributed from north to south in western China and have maintained low interpatient diversity.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

October 10, 2002

Volume

18

Issue

15

Start / End Page

1135 / 1140

Location

United States

Related Subject Headings

  • Virology
  • Substance Abuse, Intravenous
  • Software
  • Sequence Analysis, DNA
  • Sequence Alignment
  • Recombination, Genetic
  • Phylogeny
  • Molecular Sequence Data
  • Humans
  • HIV-1
 

Citation

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McClutchan, F. E., Carr, J. K., Murphy, D., Piyasirisilp, S., Gao, F., Hahn, B., … Birx, D. L. (2002). Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. AIDS Res Hum Retroviruses, 18(15), 1135–1140. https://doi.org/10.1089/088922202320567879
McClutchan, F. E., J. K. Carr, D. Murphy, S. Piyasirisilp, F. Gao, B. Hahn, X. -. F. Yu, C. Beyrer, and D. L. Birx. “Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China.AIDS Res Hum Retroviruses 18, no. 15 (October 10, 2002): 1135–40. https://doi.org/10.1089/088922202320567879.
McClutchan FE, Carr JK, Murphy D, Piyasirisilp S, Gao F, Hahn B, et al. Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. AIDS Res Hum Retroviruses. 2002 Oct 10;18(15):1135–40.
McClutchan, F. E., et al. “Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China.AIDS Res Hum Retroviruses, vol. 18, no. 15, Oct. 2002, pp. 1135–40. Pubmed, doi:10.1089/088922202320567879.
McClutchan FE, Carr JK, Murphy D, Piyasirisilp S, Gao F, Hahn B, Yu X-F, Beyrer C, Birx DL. Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. AIDS Res Hum Retroviruses. 2002 Oct 10;18(15):1135–1140.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

October 10, 2002

Volume

18

Issue

15

Start / End Page

1135 / 1140

Location

United States

Related Subject Headings

  • Virology
  • Substance Abuse, Intravenous
  • Software
  • Sequence Analysis, DNA
  • Sequence Alignment
  • Recombination, Genetic
  • Phylogeny
  • Molecular Sequence Data
  • Humans
  • HIV-1