Skip to main content
Journal cover image

Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O.

Publication ,  Journal Article
Yang, C; Gao, F; Fonjungo, PN; Zekeng, L; van der Groen, G; Pieniazek, D; Schable, C; Lal, RB
Published in: AIDS Res Hum Retroviruses
July 20, 2000

The molecular diversity and phylogenetic relationship of 22 HIV-1 group O strains were examined on the basis of the protease gene and the N-terminal region of gp41env. Analysis of the newly characterized protease sequences with 12 reference sequences revealed no specific clustering patterns, despite the distinct geographic locations of the specimens. In contrast, analysis of the newly sequenced gp41 sequences with 34 published sequences revealed two distinct clusters, each represented by one full-length sequence (MVP5180 and ANT-70). Further, four of the specimens classified as group O in the protease region clustered with group M in the gp41 region (three subtype A and one subtype G, respectively), suggesting dual and/or recombinant infections with HIV-1 groups M and O. The presence of two distinct clusters in the gp41 region indicates at least two possible subtypes within group O viruses, and this may provide useful information regarding molecular epidemiological studies of group O infections.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

July 20, 2000

Volume

16

Issue

11

Start / End Page

1075 / 1081

Location

United States

Related Subject Headings

  • Virology
  • Sequence Analysis, DNA
  • Phylogeny
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • HIV Protease
  • HIV Infections
  • HIV Envelope Protein gp41
  • Genes, env
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, C., Gao, F., Fonjungo, P. N., Zekeng, L., van der Groen, G., Pieniazek, D., … Lal, R. B. (2000). Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. AIDS Res Hum Retroviruses, 16(11), 1075–1081. https://doi.org/10.1089/08892220050075345
Yang, C., F. Gao, P. N. Fonjungo, L. Zekeng, G. van der Groen, D. Pieniazek, C. Schable, and R. B. Lal. “Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O.AIDS Res Hum Retroviruses 16, no. 11 (July 20, 2000): 1075–81. https://doi.org/10.1089/08892220050075345.
Yang C, Gao F, Fonjungo PN, Zekeng L, van der Groen G, Pieniazek D, et al. Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. AIDS Res Hum Retroviruses. 2000 Jul 20;16(11):1075–81.
Yang, C., et al. “Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O.AIDS Res Hum Retroviruses, vol. 16, no. 11, July 2000, pp. 1075–81. Pubmed, doi:10.1089/08892220050075345.
Yang C, Gao F, Fonjungo PN, Zekeng L, van der Groen G, Pieniazek D, Schable C, Lal RB. Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. AIDS Res Hum Retroviruses. 2000 Jul 20;16(11):1075–1081.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

July 20, 2000

Volume

16

Issue

11

Start / End Page

1075 / 1081

Location

United States

Related Subject Headings

  • Virology
  • Sequence Analysis, DNA
  • Phylogeny
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • HIV Protease
  • HIV Infections
  • HIV Envelope Protein gp41
  • Genes, env