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Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.

Publication ,  Journal Article
Fonjungo, PN; Mpoudi, EN; Torimiro, JN; Alemnji, GA; Eno, LT; Nkengasong, JN; Gao, F; Rayfield, M; Folks, TM; Pieniazek, D; Lal, RB
Published in: AIDS Res Hum Retroviruses
September 1, 2000

Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41. 98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unlinked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in this population.

Duke Scholars

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Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

September 1, 2000

Volume

16

Issue

13

Start / End Page

1319 / 1324

Location

United States

Related Subject Headings

  • Virology
  • Sequence Analysis, DNA
  • Phylogeny
  • Peptide Fragments
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120
 

Citation

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Fonjungo, P. N., Mpoudi, E. N., Torimiro, J. N., Alemnji, G. A., Eno, L. T., Nkengasong, J. N., … Lal, R. B. (2000). Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. AIDS Res Hum Retroviruses, 16(13), 1319–1324. https://doi.org/10.1089/08892220050117087
Fonjungo, P. N., E. N. Mpoudi, J. N. Torimiro, G. A. Alemnji, L. T. Eno, J. N. Nkengasong, F. Gao, et al. “Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.AIDS Res Hum Retroviruses 16, no. 13 (September 1, 2000): 1319–24. https://doi.org/10.1089/08892220050117087.
Fonjungo PN, Mpoudi EN, Torimiro JN, Alemnji GA, Eno LT, Nkengasong JN, et al. Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1319–24.
Fonjungo, P. N., et al. “Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.AIDS Res Hum Retroviruses, vol. 16, no. 13, Sept. 2000, pp. 1319–24. Pubmed, doi:10.1089/08892220050117087.
Fonjungo PN, Mpoudi EN, Torimiro JN, Alemnji GA, Eno LT, Nkengasong JN, Gao F, Rayfield M, Folks TM, Pieniazek D, Lal RB. Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon. AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1319–1324.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

September 1, 2000

Volume

16

Issue

13

Start / End Page

1319 / 1324

Location

United States

Related Subject Headings

  • Virology
  • Sequence Analysis, DNA
  • Phylogeny
  • Peptide Fragments
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120