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Timing the ancestor of the HIV-1 pandemic strains.

Publication ,  Journal Article
Korber, B; Muldoon, M; Theiler, J; Gao, F; Gupta, R; Lapedes, A; Hahn, BH; Wolinsky, S; Bhattacharya, T
Published in: Science
June 9, 2000

HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 9, 2000

Volume

288

Issue

5472

Start / End Page

1789 / 1796

Location

United States

Related Subject Headings

  • Zoonoses
  • United States
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Phylogeny
  • Pan troglodytes
  • Likelihood Functions
  • Humans
 

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Korber, B., Muldoon, M., Theiler, J., Gao, F., Gupta, R., Lapedes, A., … Bhattacharya, T. (2000). Timing the ancestor of the HIV-1 pandemic strains. Science, 288(5472), 1789–1796. https://doi.org/10.1126/science.288.5472.1789
Korber, B., M. Muldoon, J. Theiler, F. Gao, R. Gupta, A. Lapedes, B. H. Hahn, S. Wolinsky, and T. Bhattacharya. “Timing the ancestor of the HIV-1 pandemic strains.Science 288, no. 5472 (June 9, 2000): 1789–96. https://doi.org/10.1126/science.288.5472.1789.
Korber B, Muldoon M, Theiler J, Gao F, Gupta R, Lapedes A, et al. Timing the ancestor of the HIV-1 pandemic strains. Science. 2000 Jun 9;288(5472):1789–96.
Korber, B., et al. “Timing the ancestor of the HIV-1 pandemic strains.Science, vol. 288, no. 5472, June 2000, pp. 1789–96. Pubmed, doi:10.1126/science.288.5472.1789.
Korber B, Muldoon M, Theiler J, Gao F, Gupta R, Lapedes A, Hahn BH, Wolinsky S, Bhattacharya T. Timing the ancestor of the HIV-1 pandemic strains. Science. 2000 Jun 9;288(5472):1789–1796.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 9, 2000

Volume

288

Issue

5472

Start / End Page

1789 / 1796

Location

United States

Related Subject Headings

  • Zoonoses
  • United States
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Phylogeny
  • Pan troglodytes
  • Likelihood Functions
  • Humans