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Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.

Publication ,  Journal Article
Karlsson, GB; Gao, F; Robinson, J; Hahn, B; Sodroski, J
Published in: J Virol
September 1996

Previous observations that the gp120 envelope glycoprotein contents of some primary, clade B human immunodeficiency virus type 1 (HIV-1) isolates were higher than those of laboratory-passaged HIV-1 isolates suggested the hypothesis that increased envelope glycoprotein spike density or stability contributes to the relative neutralization resistance of the primary viruses. To test this, the structural, replicative, and neutralization properties of a panel of recombinant viruses with HIV-1 envelope glycoproteins from divergent clades were examined in an env complementation assay. In this system, although the spike density and stability of envelope glycoproteins from primary HIV-1 isolates were not greater than those from a laboratory-adapted isolate, relative resistance to neutralizing antibodies and soluble CD4 was observed for the viruses with primary envelope glycoproteins. Thus, neither high envelope glycoprotein spike density nor stability is necessary for the relative neutralization resistance of primary HIV-1 viruses.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

September 1996

Volume

70

Issue

9

Start / End Page

6136 / 6142

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Virion
  • Transfection
  • T-Lymphocytes
  • Recombinant Fusion Proteins
  • Neutralization Tests
  • Kinetics
  • Humans
  • Hela Cells
 

Citation

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Karlsson, G. B., Gao, F., Robinson, J., Hahn, B., & Sodroski, J. (1996). Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses. J Virol, 70(9), 6136–6142. https://doi.org/10.1128/JVI.70.9.6136-6142.1996
Karlsson, G. B., F. Gao, J. Robinson, B. Hahn, and J. Sodroski. “Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.J Virol 70, no. 9 (September 1996): 6136–42. https://doi.org/10.1128/JVI.70.9.6136-6142.1996.
Karlsson, G. B., et al. “Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.J Virol, vol. 70, no. 9, Sept. 1996, pp. 6136–42. Pubmed, doi:10.1128/JVI.70.9.6136-6142.1996.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

September 1996

Volume

70

Issue

9

Start / End Page

6136 / 6142

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Virion
  • Transfection
  • T-Lymphocytes
  • Recombinant Fusion Proteins
  • Neutralization Tests
  • Kinetics
  • Humans
  • Hela Cells