Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.
Publication
, Journal Article
Sutow, WW; George, S; Lowman, JT; Starling, KA; Humphrey, GB; Haggard, ME; Vietti, TJ
Published in: Med Pediatr Oncol
1976
Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L-asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. A history of prior resistance to prednisone and vincristine significantly reduced the response rate.
Duke Scholars
Published In
Med Pediatr Oncol
DOI
ISSN
0098-1532
Publication Date
1976
Volume
2
Issue
4
Start / End Page
387 / 395
Location
United States
Related Subject Headings
- Vincristine
- Prednisone
- Oncology & Carcinogenesis
- Leukemia
- Infant
- Hyperglycemia
- Humans
- Drug Hypersensitivity
- Drug Evaluation
- Daunorubicin
Citation
APA
Chicago
ICMJE
MLA
NLM
Sutow, W. W., George, S., Lowman, J. T., Starling, K. A., Humphrey, G. B., Haggard, M. E., & Vietti, T. J. (1976). Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. Med Pediatr Oncol, 2(4), 387–395. https://doi.org/10.1002/mpo.2950020405
Sutow, W. W., S. George, J. T. Lowman, K. A. Starling, G. B. Humphrey, M. E. Haggard, and T. J. Vietti. “Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.” Med Pediatr Oncol 2, no. 4 (1976): 387–95. https://doi.org/10.1002/mpo.2950020405.
Sutow WW, George S, Lowman JT, Starling KA, Humphrey GB, Haggard ME, et al. Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. Med Pediatr Oncol. 1976;2(4):387–95.
Sutow, W. W., et al. “Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.” Med Pediatr Oncol, vol. 2, no. 4, 1976, pp. 387–95. Pubmed, doi:10.1002/mpo.2950020405.
Sutow WW, George S, Lowman JT, Starling KA, Humphrey GB, Haggard ME, Vietti TJ. Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. Med Pediatr Oncol. 1976;2(4):387–395.
Published In
Med Pediatr Oncol
DOI
ISSN
0098-1532
Publication Date
1976
Volume
2
Issue
4
Start / End Page
387 / 395
Location
United States
Related Subject Headings
- Vincristine
- Prednisone
- Oncology & Carcinogenesis
- Leukemia
- Infant
- Hyperglycemia
- Humans
- Drug Hypersensitivity
- Drug Evaluation
- Daunorubicin