Evidence-based oral transmucosal fentanyl citrate (OTFC) dosing guidelines.
OBJECTIVE: To review the evidence for dosing and efficacy of oral transmucosal fentanyl citrate in the management of pain and produce dosing guidelines. DESIGN: The scientific literature pertaining to oral transmucosal fentanyl citrate was reviewed, focusing upon its pharmacology and clinical experience with use in cancer and noncancer pain. Emphasis was upon published, peer-reviewed English language articles. RESULTS: Information was crucially examined and synthesized into guidelines for use and dosing of oral transmucosal fentanyl citrate in cancer and noncancer pain. CONCLUSIONS: Oral transmucosal fentanyl citrate is a potent opioid delivery system, which, when used appropriately, is an effective treatment option for pain. Adherence to guidelines should promote its safe and efficacious use in a variety of clinical pain management settings.
Duke Scholars
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Related Subject Headings
- Pain
- Male
- Humans
- Guidelines as Topic
- Fentanyl
- Evidence-Based Medicine
- Clinical Trials as Topic
- Anesthesiology
- Analgesics, Opioid
- Administration, Oral
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Pain
- Male
- Humans
- Guidelines as Topic
- Fentanyl
- Evidence-Based Medicine
- Clinical Trials as Topic
- Anesthesiology
- Analgesics, Opioid
- Administration, Oral