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Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support.

Publication ,  Journal Article
Olsen, GA; Gockerman, JP; Bast, RC; Borowitz, M; Peters, WP
Published in: Transplantation
July 1988

Altered immunologic reconstitution is observed in patients treated with high-dose chemotherapy consisting of cyclophosphamide, cisplatin, and carmustine, melphalan, or etoposide with autologous bone marrow support, and it is similar to that seen in patients treated with high-dose chemoradiotherapy and allogeneic bone marrow transplantation. A decrease in the absolute number and percentage of B cell and CD4 antigen-positive cells and an increase in the absolute number and percentage of CD8 and Ia antigen-positive cells occur along with a decrease in the CD4/CD8 ratio that persists for 6-12 months after high-dose chemotherapy and autologous bone marrow support. These changes have been associated with four serious infectious episodes usually seen only in immunocompromised patients. The above changes were not seen in patients treated with high-dose busulfan, a drug that has relatively specific effects on granulocytes. It is postulated that these alterations result from effects of chemotherapy on the residual lymphocytes or on the environment of repopulating lymphocytes. Functional studies of lymphocyte populations during immunologic reconstitution after standard-dose combination chemotherapy and high-dose chemotherapy with autologous bone marrow support are needed.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 1988

Volume

46

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Surgery
  • Lymphocytes
  • Leukocyte Count
  • Immunity
  • Bone Marrow Transplantation
  • Antineoplastic Combined Chemotherapy Protocols
  • Antibodies, Viral
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Olsen, G. A., Gockerman, J. P., Bast, R. C., Borowitz, M., & Peters, W. P. (1988). Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support. Transplantation, 46(1), 57–60. https://doi.org/10.1097/00007890-198807000-00009
Olsen, G. A., J. P. Gockerman, R. C. Bast, M. Borowitz, and W. P. Peters. “Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support.Transplantation 46, no. 1 (July 1988): 57–60. https://doi.org/10.1097/00007890-198807000-00009.
Olsen GA, Gockerman JP, Bast RC, Borowitz M, Peters WP. Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support. Transplantation. 1988 Jul;46(1):57–60.
Olsen, G. A., et al. “Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support.Transplantation, vol. 46, no. 1, July 1988, pp. 57–60. Pubmed, doi:10.1097/00007890-198807000-00009.
Olsen GA, Gockerman JP, Bast RC, Borowitz M, Peters WP. Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support. Transplantation. 1988 Jul;46(1):57–60.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 1988

Volume

46

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Surgery
  • Lymphocytes
  • Leukocyte Count
  • Immunity
  • Bone Marrow Transplantation
  • Antineoplastic Combined Chemotherapy Protocols
  • Antibodies, Viral
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences