Skip to main content
Journal cover image

Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants.

Publication ,  Journal Article
Natarajan, G; Shankaran, S; McDonald, SA; Das, A; Ehrenkranz, RA; Goldberg, RN; Stoll, BJ; Tyson, JE; Higgins, RD; Schendel, D; Hougaard, DM ...
Published in: Pediatr Cardiol
January 2013

Permanent ductal closure involves anatomic remodeling, in which transforming growth factor (TGF)-β appears to play a role. Our objective was to evaluate the relationship, if any, between blood spot TGF-β on day 3 and day 7 of life and patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. Prospective observational study involving ELBW infants (n = 968) in the National Institute of Child Health and Human Development Neonatal Research Network who had TGF-β measured on filter paper spot blood samples using a Luminex assay. Infants with a PDA (n = 493) were significantly more immature, had lower birth weights, and had higher rates of respiratory distress syndrome than those without PDA (n = 475). TGF-β on days 3 and 7 of life, respectively, were significantly lower among neonates with PDA (median 1,177 pg/ml [range 642-1,896]; median 1,386 pg/ml [range 868-1,913]) compared with others without PDA (median 1,334 pg/ml [range 760-2,064]; median 1,712 pg/ml [range 1,014-2,518 pg/ml]). The significant difference persisted when death or PDA was considered a composite outcome. TGF-β levels were not significantly different among subgroups of infants with PDA who were not treated (n = 51) versus those who were treated medically (n = 283) or by surgical ligation (n = 159). TGF-β was not a significant predictor of death or PDA (day 3 odds ratio [OR] 0.99, 95 % confidence interval [CI] 0.83-1.17; day 7 OR 0.88, 95 % CI 0.74-1.04) on adjusted analyses. Our results suggest that blood spot TGF-β alone is unlikely to be a reliable biomarker of a clinically significant PDA or its responsiveness to treatment.

Duke Scholars

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

January 2013

Volume

34

Issue

1

Start / End Page

149 / 154

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Respiratory Distress Syndrome, Newborn
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Infant
  • Humans
  • Female
  • Ductus Arteriosus, Patent
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Natarajan, G., Shankaran, S., McDonald, S. A., Das, A., Ehrenkranz, R. A., Goldberg, R. N., … Carlo, W. A. (2013). Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants. Pediatr Cardiol, 34(1), 149–154. https://doi.org/10.1007/s00246-012-0404-7
Natarajan, Girija, Seetha Shankaran, Scott A. McDonald, Abhik Das, Richard A. Ehrenkranz, Ronald N. Goldberg, Barbara J. Stoll, et al. “Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants.Pediatr Cardiol 34, no. 1 (January 2013): 149–54. https://doi.org/10.1007/s00246-012-0404-7.
Natarajan G, Shankaran S, McDonald SA, Das A, Ehrenkranz RA, Goldberg RN, et al. Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants. Pediatr Cardiol. 2013 Jan;34(1):149–54.
Natarajan, Girija, et al. “Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants.Pediatr Cardiol, vol. 34, no. 1, Jan. 2013, pp. 149–54. Pubmed, doi:10.1007/s00246-012-0404-7.
Natarajan G, Shankaran S, McDonald SA, Das A, Ehrenkranz RA, Goldberg RN, Stoll BJ, Tyson JE, Higgins RD, Schendel D, Hougaard DM, Skogstrand K, Thorsen P, Carlo WA. Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants. Pediatr Cardiol. 2013 Jan;34(1):149–154.
Journal cover image

Published In

Pediatr Cardiol

DOI

EISSN

1432-1971

Publication Date

January 2013

Volume

34

Issue

1

Start / End Page

149 / 154

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Respiratory Distress Syndrome, Newborn
  • Prospective Studies
  • Male
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Infant
  • Humans
  • Female
  • Ductus Arteriosus, Patent