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Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.

Publication ,  Journal Article
Carlo, WA; McDonald, SA; Tyson, JE; Stoll, BJ; Ehrenkranz, RA; Shankaran, S; Goldberg, RN; Das, A; Schendel, D; Thorsen, P; Skogstrand, K ...
Published in: J Pediatr
December 2011

OBJECTIVE: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. STUDY DESIGN: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. RESULTS: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. CONCLUSIONS: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.

Duke Scholars

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2011

Volume

159

Issue

6

Start / End Page

919 / 25.e3

Location

United States

Related Subject Headings

  • Pediatrics
  • Nervous System Diseases
  • Nervous System
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Humans
  • Cytokines
  • Cohort Studies
  • Child Development
  • Cerebral Palsy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carlo, W. A., McDonald, S. A., Tyson, J. E., Stoll, B. J., Ehrenkranz, R. A., Shankaran, S., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2011). Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. J Pediatr, 159(6), 919-25.e3. https://doi.org/10.1016/j.jpeds.2011.05.042
Carlo, Waldemar A., Scott A. McDonald, Jon E. Tyson, Barbara J. Stoll, Richard A. Ehrenkranz, Seetha Shankaran, Ronald N. Goldberg, et al. “Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.J Pediatr 159, no. 6 (December 2011): 919-25.e3. https://doi.org/10.1016/j.jpeds.2011.05.042.
Carlo WA, McDonald SA, Tyson JE, Stoll BJ, Ehrenkranz RA, Shankaran S, et al. Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. J Pediatr. 2011 Dec;159(6):919-25.e3.
Carlo, Waldemar A., et al. “Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.J Pediatr, vol. 159, no. 6, Dec. 2011, pp. 919-25.e3. Pubmed, doi:10.1016/j.jpeds.2011.05.042.
Carlo WA, McDonald SA, Tyson JE, Stoll BJ, Ehrenkranz RA, Shankaran S, Goldberg RN, Das A, Schendel D, Thorsen P, Skogstrand K, Hougaard DM, Oh W, Laptook AR, Duara S, Fanaroff AA, Donovan EF, Korones SB, Stevenson DK, Papile L-A, Finer NN, O’Shea TM, Poindexter BB, Wright LL, Ambalavanan N, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. J Pediatr. 2011 Dec;159(6):919–25.e3.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2011

Volume

159

Issue

6

Start / End Page

919 / 25.e3

Location

United States

Related Subject Headings

  • Pediatrics
  • Nervous System Diseases
  • Nervous System
  • Infant, Newborn
  • Infant, Extremely Low Birth Weight
  • Humans
  • Cytokines
  • Cohort Studies
  • Child Development
  • Cerebral Palsy