Host genetics and HIV-1: the final phase?
This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.
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Related Subject Headings
- Virology
- Treatment Outcome
- Models, Biological
- Infection Control
- Humans
- Host-Pathogen Interactions
- HIV-1
- HIV Infections
- Genetic Variation
- Disease Progression
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Virology
- Treatment Outcome
- Models, Biological
- Infection Control
- Humans
- Host-Pathogen Interactions
- HIV-1
- HIV Infections
- Genetic Variation
- Disease Progression