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Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients.

Publication ,  Journal Article
Goldstein, KM; Gluckman, S; Mounzer, K
Published in: AIDS Read
September 2008

With an improved life expectancy, HIV-positive patients now face interactions between antiretroviral therapy and medications for chronic medical problems. One example is thromboembolism and its treatment with oral anticoagulants. To date, there have been 9 case reports documenting drug interactions between oral anticoagulants and antiretroviral agents. We conducted a retrospective case series to better understand the challenges of anticoagulation management in HIV-positive patients receiving antiretroviral therapy. Of the 9 cases evaluated, the median percentage of international normalized ratio (INR) measurements of blood clotting time within the therapeutic range was 28.6%. Of those INRs outside the therapeutic range, 50.5% were subtherapeutic and 21.2% were supratherapeutic. A heightened awareness of the potential difficulty in achieving adequate anticoagulation in patients on antiretroviral regimens is warranted.

Duke Scholars

Published In

AIDS Read

ISSN

1053-0894

Publication Date

September 2008

Volume

18

Issue

9

Start / End Page

480 / 489

Location

United States

Related Subject Headings

  • Virology
  • Retrospective Studies
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • Female
  • Anticoagulants
  • Anti-HIV Agents
  • Adult
 

Citation

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Goldstein, K. M., Gluckman, S., & Mounzer, K. (2008). Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients. AIDS Read, 18(9), 480–489.
Goldstein, Karen M., Stephen Gluckman, and Karam Mounzer. “Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients.AIDS Read 18, no. 9 (September 2008): 480–89.
Goldstein KM, Gluckman S, Mounzer K. Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients. AIDS Read. 2008 Sep;18(9):480–9.
Goldstein, Karen M., et al. “Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients.AIDS Read, vol. 18, no. 9, Sept. 2008, pp. 480–89.
Goldstein KM, Gluckman S, Mounzer K. Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients. AIDS Read. 2008 Sep;18(9):480–489.

Published In

AIDS Read

ISSN

1053-0894

Publication Date

September 2008

Volume

18

Issue

9

Start / End Page

480 / 489

Location

United States

Related Subject Headings

  • Virology
  • Retrospective Studies
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • Female
  • Anticoagulants
  • Anti-HIV Agents
  • Adult