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A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Publication ,  Journal Article
Helgadottir, A; Thorleifsson, G; Manolescu, A; Gretarsdottir, S; Blondal, T; Jonasdottir, A; Jonasdottir, A; Sigurdsson, A; Baker, A; Palsson, A ...
Published in: Science
June 8, 2007

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 8, 2007

Volume

316

Issue

5830

Start / End Page

1491 / 1493

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Homozygote
  • Heterozygote
  • Haplotypes
 

Citation

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Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., … Stefansson, K. (2007). A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science, 316(5830), 1491–1493. https://doi.org/10.1126/science.1142842
Helgadottir, Anna, Gudmar Thorleifsson, Andrei Manolescu, Solveig Gretarsdottir, Thorarinn Blondal, Aslaug Jonasdottir, Adalbjorg Jonasdottir, et al. “A common variant on chromosome 9p21 affects the risk of myocardial infarction.Science 316, no. 5830 (June 8, 2007): 1491–93. https://doi.org/10.1126/science.1142842.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007 Jun 8;316(5830):1491–3.
Helgadottir, Anna, et al. “A common variant on chromosome 9p21 affects the risk of myocardial infarction.Science, vol. 316, no. 5830, June 2007, pp. 1491–93. Pubmed, doi:10.1126/science.1142842.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007 Jun 8;316(5830):1491–1493.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 8, 2007

Volume

316

Issue

5830

Start / End Page

1491 / 1493

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Homozygote
  • Heterozygote
  • Haplotypes