Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones.
Publication
, Journal Article
Grant, AO; Wendt, DJ
Published in: Trends Pharmacol Sci
September 1992
The Na+ channel is an important target for the action of antiarrhythmic drugs. Application of contemporary biophysical, biochemical and molecular biological techniques have added considerably to our knowledge of its structure, function, modulation and block by antiarrhythmic drugs. The increased mortality from the use of these drugs for prophylaxis of cardiac arrhythmias has forced a re-evaluation of their use and of the entire pharmacological strategy of arrhythmia management. Gus Grant and David Wendt review recent studies on the block and modulation of cardiac Na+ channels and the place of Na+ channel blockers in future antiarrhythmic drug development.
Duke Scholars
Published In
Trends Pharmacol Sci
DOI
ISSN
0165-6147
Publication Date
September 1992
Volume
13
Issue
9
Start / End Page
352 / 358
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Sodium Channels
- Pharmacology & Pharmacy
- Neurotransmitter Agents
- Myocardium
- Hormones
- Heart
- Binding, Competitive
- Anti-Arrhythmia Agents
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Grant, A. O., & Wendt, D. J. (1992). Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones. Trends Pharmacol Sci, 13(9), 352–358. https://doi.org/10.1016/0165-6147(92)90108-i
Grant, A. O., and D. J. Wendt. “Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones.” Trends Pharmacol Sci 13, no. 9 (September 1992): 352–58. https://doi.org/10.1016/0165-6147(92)90108-i.
Grant AO, Wendt DJ. Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones. Trends Pharmacol Sci. 1992 Sep;13(9):352–8.
Grant, A. O., and D. J. Wendt. “Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones.” Trends Pharmacol Sci, vol. 13, no. 9, Sept. 1992, pp. 352–58. Pubmed, doi:10.1016/0165-6147(92)90108-i.
Grant AO, Wendt DJ. Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones. Trends Pharmacol Sci. 1992 Sep;13(9):352–358.
Published In
Trends Pharmacol Sci
DOI
ISSN
0165-6147
Publication Date
September 1992
Volume
13
Issue
9
Start / End Page
352 / 358
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Sodium Channels
- Pharmacology & Pharmacy
- Neurotransmitter Agents
- Myocardium
- Hormones
- Heart
- Binding, Competitive
- Anti-Arrhythmia Agents
- Animals