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Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man.

Publication ,  Journal Article
Greenfield, JC; Tindall, GT
Published in: The Journal of clinical investigation
July 1968

Internal carotid artery blood flow and arterial pressure were measured with a sine-wave electromagnetic flowmeter and a pressure transducer in 22 patients during control period and after the intravenous and intracarotid administration of norepinephrine, epinephrine, and angiotensin. Intravenous infusion of both norepinephrine and angiotensin was accompanied by an increase in cerebral vascular resistance. Administration of norepinephrine, epinephrine, and angiotensin into the internal carotid artery failed to alter blood flow immediately. However, when the systemic blood pressure increased, a concomitant passive rise in blood flow did not occur. Thus, at this time cerebral vascular resistance was significantly increased. It is concluded that these drugs do not have a direct action on the cerebral vessels, but that the increased cerebral vascular resistance after their administration is due to autoregulation or to a combination of autoregulation and reduced arterial carbon dioxide pressure (P(CO2)) secondary to hyperventilation. Similar studies were carried out in the external carotid artery of six patients. Within 10 sec after injection blood flow was markedly reduced, indicating a direct vasoconstricting action on this vascular bed.

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

July 1968

Volume

47

Issue

7

Start / End Page

1672 / 1684

Related Subject Headings

  • Vascular Resistance
  • Norepinephrine
  • Male
  • Injections, Intra-Articular
  • Infusions, Parenteral
  • Immunology
  • Humans
  • Epinephrine
  • Cerebrovascular Circulation
  • Carotid Arteries
 

Citation

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ICMJE
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Greenfield, J. C., & Tindall, G. T. (1968). Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man. The Journal of Clinical Investigation, 47(7), 1672–1684. https://doi.org/10.1172/jci105858
Greenfield, J. C., and G. T. Tindall. “Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man.The Journal of Clinical Investigation 47, no. 7 (July 1968): 1672–84. https://doi.org/10.1172/jci105858.
Greenfield JC, Tindall GT. Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man. The Journal of clinical investigation. 1968 Jul;47(7):1672–84.
Greenfield, J. C., and G. T. Tindall. “Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man.The Journal of Clinical Investigation, vol. 47, no. 7, July 1968, pp. 1672–84. Epmc, doi:10.1172/jci105858.
Greenfield JC, Tindall GT. Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man. The Journal of clinical investigation. 1968 Jul;47(7):1672–1684.

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

July 1968

Volume

47

Issue

7

Start / End Page

1672 / 1684

Related Subject Headings

  • Vascular Resistance
  • Norepinephrine
  • Male
  • Injections, Intra-Articular
  • Infusions, Parenteral
  • Immunology
  • Humans
  • Epinephrine
  • Cerebrovascular Circulation
  • Carotid Arteries